Dissertation committee:
Κελέκης Νικόλαος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κελέκης Χρυσόστομος - Αλέξιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αλεξοπούλου Ευθυμία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Φιλιππιάδης Δημήτριος, Αν. Καθηγητής, Ιατρική Σχολής, ΕΚΠΑ
Παπακωνσταντίνου Ολυμπία, Επ. Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σπηλιόπουλος Σταύρος, Αν. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Βελονάκης Γεώργιος, Επ. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Summary:
Objectives:
To retrospectively compare and evaluate ablation zone volume and its reduction from baseline to 1 month follow-up post percutaneous microwave ablation (MWA) between healthy and cirrhotic liver parenchyma.
Methods:
Institutional database research identified 84 patients (118 hepatic tumors) who underwent percutaneous MWA with the same system. Caudal-right lobe ratio was applied to distinguish cirrhotic (n = 51) and healthy (n = 67) group; ITK-SNAP software was used to quantify ablation zone volume. Long (LAD) and short 1 (SAD-1) and 2 (SAD-2) axis, tumor size diameter (mm) and volume (cm³) of the ablation zones were evaluated for each treated lesion in both groups at baseline (immediately post ablation) and at 1 month follow-up.
Results:
There was no significant difference comparing ablation zone volumes at baseline (healthy group: mean ablation volume 14.84 cm³ versus cirrhotic group: mean ablation volume 17.85 cm³, p = 0.31) and 1 month post ablation (healthy group: mean ablation volume 9.15 cm³ versus cirrhotic group: mean ablation volume 11.58 cm³, p = 0.24). When both “healthy” and “cirrhotic” liver group were evaluated independently there was a significant difference of ablation volumes reduction (p-value < 0.001) from baseline to 1 month follow-up. When both groups were compared based on reduction (35.12–38.34%) there was no significant difference in ablation zone volumes (p-value = 0.77).
Conclusions:
Percutaneous MWA results in ablation zones of a comparable volume in both healthy and cirrhotic liver parenchyma. Both cirrhotic and healthy liver parenchyma experience a similar significant reduction of ablation zone volume at 1 month post therapy.
Keywords:
Interventional Radiology, Liver, MWA, Volumetry, Tumor
