Unit:
Department of NursingLibrary of the School of Health Sciences
Dissertation committee:
Ιωάννης Κακλαμάνος, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Γεράσιμος Μπονάτσος, Ομότιμος Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Κωνσταντίνος Μπίρμπας, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Αντώνιος Σταματάκης, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Κωνσταντίνος Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Θεόδωρος Μαριόλης-Σαψάκος, Αναπληρωτής Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Πέτρος Γαλανής, Επίκουρος Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Original Title:
Διερεύνηση της χρήσης του κυκλοφορούντος μακρού μη κωδικοποιητικού RNA (LncRNA) HOTTIP ως βιοδείκτη στον καρκίνο του μαστού
Translated title:
Investigation of the use of circulating long non-coding RNA HOXA transcript at the distal tip (LncRNA HOTTIP) as a biomarker in breast cancer
Summary:
Being the most prevalent cancer in women globally, breast cancer poses a serious threat to global health. For a successful course of therapy and better patient outcomes, early identification of breast cancer is essential. Despite improvements in screening and diagnostic methods for early breast cancer detection, more accurate and trustworthy biomarkers are still required for the diagnosis, prognosis, and follow-up of this illness.
Non-coding RNAs (ncRNAs) have attracted a great deal of interest in recent years because of their function in cancer biology. In several malignancies, including breast cancer, long non-coding RNAs (lncRNAs), a subclass of ncRNAs, have become potential biomarkers and therapeutic targets. HOTTIP (HOXA transcript at the distal tip), one of the many lncRNAs investigated, has demonstrated potential as a possible biomarker for breast cancer.
The HOXA locus is the source of the well-studied lncRNA HOTTIP, which has been linked to several cellular functions such cell division, migration, and proliferation. Additionally, a growing body of research indicates that dysregulated HOTTIP expression is linked to the onset and progression of disease, particularly breast cancer. This makes HOTTIP an attractive molecule to research for its possible application in the detection and treatment of breast cancer.
The purpose of this study is to conduct a thorough examination of the usage of circulating HOTTIP as a breast cancer biomarker. We will talk about the dysregulation of HOTTIP in breast cancer, the current knowledge of its molecular roles, and its potential as a non-invasive diagnostic and prognostic tool. We will also go through the difficulties and possibilities of using circulating lncRNAs as biomarkers in clinical practice, including concerns like sensitivity, specificity, and standardization of detection techniques.
Through this research, we want to add to the expanding body of information about non- coding RNAs in breast cancer and maybe progress the creation of new and improved methods for the early identification and treatment of this common and deadly condition.
Main subject category:
Health Sciences
Keywords:
RNA, Prognostic factor, LncRNA, HOTTIP
Number of references:
223
