Faculty of Medicine
Library of the School of Health Sciences

2024-03-21

2024

Mandila Christina

Ιωάννης Παρίσης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεράσιμος Φιλιππάτος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευστάθιος Ηλιοδρομίτης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λουκιανός Ραλλίδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιγνάτιος Οικονομίδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευτυχία Πολυζωγοπούλου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Φαρμάκης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Η επίδραση της νευρομυϊκής ηλεκτρικής διέγερσης των σκελετικών μυών των κάτω άκρων στους άνδρες και τις γυναίκες με χρόνια καρδιακή ανεπάρκεια

Greek

Effects of functional electrical stimulation of lower limb muscles on men and women with chronic heart failure

Purpose: Functional electrical stimulation (FES) of lower limb is an safe and beneficial alternative to physical training in chronic heart failure (CHF) patients. Although it improves exercise capacity in CHF, we performed a randomised, placebo-controlled study to investigate its effects on long-term clinical outcomes and if there are differences between men and women.
Methods: We randomly assigned 120 patients, (56,7% male aged 71±8 years), with stable CHF (New York Heart Association(NYHA) class II/III (63% / 37%), mean left ventricular ejection fraction 28±5%), to either a 6-week functional electrical stimulation training programme or placebo. Patients were followed for up to 19 months for death and/or hospitalisation due to CHF decompensation.
Results: Mortality did not differ between groups (log rank test P=0.680), while the heart failure-related hospitalisation rate was significantly lower in the FES group (hazard ratio (HR) 0.40, 95% confidence interval (CI) 0.21–0.78, P = 0.007). The latter difference remained significant after adjustment for prognostic factors: age, gender, baseline NYHA class and left ventricular ejection fraction (HR 0.22, 95% CI 0.10–0.46, P<0.001). Compared to placebo, FES training was associated with a lower occurrence of the composite endpoint (death or heart failure-related hospitalisation) after adjustment for abovementioned prognostic factors (HR 0.21, 95% CI 0.103–0.435, P<0.001). However, that effect was mostly driven by the favourable change in hospitalisation rates. Among females, women randomly assigned to FES had 67% less risk for the combined end point (HR=0.33 with 95% CI=0.13-0.83, p=0.02) and 74% less risk for hospitalization ( HR=0.26 with 95% CI=0.09 to 0.76, p=0.014). No significant reduction was observed between men in the composite endpoint and hospitalizations.
Conclusions: In CHF patients, 6 weeks FES training reduced the risk of heart failure-related hospitalisations, without affecting the mortality rate. The effect of FES on the reduction of hospitalizations was statistically significant in women while in men was not statistically significant. Possibly, FES has better results in women than in men.

Health Sciences

Heart failure, FES, Women

No

0

Yes

213

110

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https://pergamos.lib.uoa.gr/uoa/dl/object/3392620