Unit:
Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεωνLibrary of the School of Health Sciences
Author:
Triantafyllou Stavroula-Evangelia
Supervisors info:
Γρουζή Ελισάβετ, Εξωτερική Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Μερκούρη Ευφροσύνη, Εξωτερική Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Μαριάννα Πολίτου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίδραση της αιμοπεταλιαφαίρεσης στα επίπεδα της θρομβοποιητίνης υγιών δοτών
Translated title:
The effect of platelet apheresis on thrombopoietin levels of healthy donors
Summary:
Thrombopoietin (Tpo) is a glycoprotein hormone produced primarily in the liver, and secondarily in the kidneys and bone marrow. It is the master regulator of thrombopoiesis that signals through the cMpl receptor, promoting the proliferation and differentiation of megakaryocytes ultimately leading to the release of new platelets into circulation. Tpo’s circulating levels are regulated by the extent of its binding to the cMpl receptors found on circulating platelets and on plasma-accessible megakaryocytes. Reduced platelet mass or number results in a high concentration of Tpo in the plasma, whereas a high number of circulating platelets will bind Tpo.
The discovery of Tpo helped to understand the pathophysiology of diseases characterized by thrombocytopenia or thrombocytosis, while it was a springboard for the development of therapeutic methods to treat thrombocytopenia targeting the Tpo/cMpl axis.
The aim of the present study is to investigate the changes in the levels of thrombopoietin (Tpo) in the serum of healthy platelet donors. The study involved 11 donors (8 men and 3 women) in whom the level of thrombopoietin and the number of platelets were determined before the platelet donation, immediately after and 5 days after. The drop in platelet count at the end of the session was obvious, reaching an average of 25.64%, which raised back to almost the same levels 5 days later. An increase of 11.2% was observed in the mean donor serum thrombopoietin concentration immediately after the end of the session. It remained at the same levels 5 days after removal. The difference in the concentration of thrombopoietin between the measurements was not statistically significant, however, they showed an inverse correlation between the level of Tpo and the number of circulating platelets in the blood of the donors.
Main subject category:
Health Sciences
Keywords:
Thrombopoiesis, Thrombopoietin, Donors, Platelets, Plateletapheresis
Number of references:
235
File:
File access is restricted only to the intranet of UoA.
Triantafyllou_Stavroula_Evangelia_MSc.pdf
3 MB
File access is restricted only to the intranet of UoA.
