Unit:
Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεωνLibrary of the School of Health Sciences
Supervisors info:
Νομικού Ευφροσύνη, Διευθύντρια, Τμήμα Αιμορροφιλικών και διαταραχών Πήξης, ΙΓΝΑ
Πολίτου Μαριάννα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μερκούρη Ευφροσύνη, Επιστημονικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίδραση των DOACs στις δοκιμασίες της πήξης
Translated title:
The effect of DOACs on coagulation tests
Summary:
Successful hemostasis is the result of a delicate balance between bleeding and clotting. Thrombotic events are among the major causes of morbidity in the developed world. The need to find the ideal anticoagulant drug that will protect as much as possible from new thrombosis and not tip the scales toward bleeding is becoming apparent. Direct Oral Anticoagulants (DOACs) came out promising to satisfy this need and quickly gained the trust of the medical community.
Purpose: The purpose of this survey is to investigate the effect of DOACs on coagulation tests and whether this effect occurs in an expected and stable manner so that they can be used to monitor and evaluate their anticoagulant activity, at least in groups of patients with increased bleeding or thrombotic risk.
Method: For the purposes of the study, blood samples were obtained from patients under observation or admitted to the ‘Hippocration’ General Hospital who were under anticoagulation with DOACs and underwent routine coagulation testing, measurement of coagulation factor levels, anti-Xa activity and thromboelastography (TEG6s).
Conclusions: Anti-Xa activity is the best method for monitoring the effect of FXa inhibitors while the efficacy of thrombin inhibitors is successfully assessed by dTT time and endogenous thrombin potential where the assay is available. Thromboelastography can also approximate the levels of these drugs in the blood and is a promising method that seems to be gaining ground in daily clinical practice.
Main subject category:
Health Sciences
Keywords:
Coagulation tests, DOACs, TEG6s
File:
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Avgoustou_Elena_Msc.pdf
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File access is restricted only to the intranet of UoA.
