Unit:
Department of DentistryΒιβλιοθήκη Οδοντιατρικής
Dissertation committee:
Καρούσης Ιωάννης, Αναπληρωτής Καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ.
Μαδιανός Φοίβος, Καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ.
Πεπελάση Ευδοξία, Καθηγήτρια, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ.
Παπαϊωάννου Βασίλειος, Αναπληρωτής Καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ.
Φουρμούζης Ιωάννης, Επίκουρος Καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ.
Μπομπέτσης Γεώργιος, Επίκουρος Καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ.
Βασιλόπουλος Σπυρίδων, Επίκουρος Καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ.
Original Title:
Επίδραση της συμπληρωματικής εφαρμογής Laser Nd:YAG στη θεραπεία της χρόνιας περιοδοντίτιδας βραδείας εξέλιξης (Σταδίου III και IV)
Translated title:
Adjunctive Nd:YAG laser irradiation in the treatment of stage III/IV periodontitis
Summary:
Objectives
The aim of this study was to investigate whether the use of adjunctive Nd:YAG (1064 nm) laser irradiation to full-mouth scaling and root planing (FM-SRP) may offer additional benefit in the clinical parameters and the systemic inflammatory status of the patient, as depicted in a variety of systemic biomarkers over FM-SRP alone, up to 12 months after treatment.
Materials and methods
A total of 60 otherwise healthy stage III/IV periodontal patients were equally distributed in 3 groups. The control group received FM-SRP. In laser A group, 1 week after FM-SRP, Nd:YAG laser irradiation was delivered in periodontal pockets with PD ≥ 4 mm using specific settings (3 W, 150 mJ, 20 Hz, 100 μs). In laser B group Nd:YAG laser irradiation was delivered twice, 1 week after FM-SRP and 1 week later with different settings compared to laser A (2 W, 200 mJ, 10 Hz, 100 μs).
Results
A significant reduction (p=0.038) ofI L-1β serum levels at the 6 month timepoint was observed for laser A group. IL-6 was found statistically significantly increased (p=0.011) in the control group at the 6-week time point, whereas no difference was reported for the laser-treated groups (laser A, laser B).
In addition, a significant improvement (p < 0.001) for all clinical parameters was observed during the entire study period, with the exception of mean CAL gain for the laser 2 group at 12 months. The percentage of pockets ≤ 4 mm was significantly higher compared to baseline for all groups throughout the study, with no inter-group differences at any time point. Patient- reported analgesic consumption was higher for laser 1 group.
Conclusions
The adjunctive use of Nd:YAG laser irradiation, prevented from IL-6 increase after FM-SRP, 6 weeks after treatment. Similarly, Nd:YAG laser irradiation (3 W, 150 mJ, 20 Hz,100 μs) was associated with significantly lower IL-1β levels, 6 months post-operatively.
In addition, the adjunctive use of Nd:YAG laser irradiation was similarly effective to FMS alone, during the entire study period. A slightly higher, though not statistically significant improvement was reported for PD at 6 and 12 months after a single post-FMS application of Nd:YAG laser for pocket epithelium removal and coagulation.
Clinical relevance
Additional Nd:YAG laser application to FM-SRP may provide a potential beneficial effect on systemic inflammation.
Trial registration number ISRCTN26692900.
Registration date 09/06/2022.
Main subject category:
Health Sciences
Keywords:
Periodontitis stage III/IV, Full-mouth scaling, Nd:YAG laser, Non-surgical periodontal treatment
Number of references:
510
File:
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