Unit:
Κατεύθυνση Ιατρική Φυσική-ΑκτινοφυσικήLibrary of the School of Health Sciences
Supervisors info:
Εμμανουήλ Παπαναστασίου, Αναπληρωτής Καθηγητής, Τμήμα Ιατρικής, ΑΠΘ
Ιωάννης Ιακώβου, Καθηγητής, Τμήμα Ιατρικής, ΑΠΘ
Αναστάσιος Σιούντας, Ομότιμος Καθηγητής, Τμήμα Ιατρικής, ΑΠΘ
Original Title:
Συσχέτιση μεταξύ ποσοτικών παραμέτρων διαγνωστικών εικόνων [68Ga]Ga-DOTA-TOC με την απορροφούμενη δόση από θεραπεία με [177Lu]Lu-DOTA-TATE σε ασθενείς με νευροενδοκρινείς όγκους
Translated title:
Correlation between quantitative parameters from [68Ga]Ga-DOTA-TOC diagnostic images and [177Lu]Lu-DOTA-TATE absorbed dose from treatment in patients with neuroendocrine tumors
Summary:
Neuroendocrine tumors (NETs) are rare heterogenous neoplasms that arise in secretory cells of the diffuse neuroendocrine system. PET/CT imaging with [68Ga]Ga-DOTA-TOC is considered the “gold standard” for patients with NETs and is also the basis for the selection of candidates for peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE. Post-treatment dosimetry is possible via SPECT/CT imaging in multiple time points. The purpose of the present work is the evaluation of the correlation between quantitative parameters, such as activity concentration and SUV (Standardized Uptake Value), extracted from pre-treatment PET/CT imaging with [68Ga]Ga-DOTA-TOC, with the corresponding parameters from post-treatment SPECT/CT images with [177Lu]Lu-DOTA-TATE, as well as with absorbed doses in lesions. Dosimetry was performed with PLANET® Onco Dose software from DOSIsoft, after the first treatment cycle for each of the 18 patients who participated in this study. The total number of lesions studied was 53, and included primary NETs, liver and lymph node metastases. Correlation was studied by means of the non-parametric Spearman correlation coefficient, both for all lesions, and separately in groups according to the type of metastasis, while it was re-investigated after removing from the sample a patient who represented a large deviation compared to the rest. From this study, a statistically significant though moderate correlation was noticed between [177Lu]Lu-DOTA-TATE absorbed dose and [68Ga]Ga-DOTA-TOC mean activity concentration (r=0.514), while it was also observed that a high uptake of [68Ga]Ga-DOTA-TOC is associated with high absorbed doses from the treatment. Moreover, correlation improves when separating lesions into liver and lymph node metastases (r=0.627 and r=0.733 respectively), and the strongest correlation between all parameters for all lesions was observed between the maximum activity concentration of [68Ga]Ga-DOTA-TOC and [177Lu]Lu-DOTA-TATE (r=0.568).
Main subject category:
Health Sciences
Keywords:
Nuclear medicine, Internal dosimetry, Theragnostics, Peptide peceptor Radionuclide therapy, PET-CT, Neuroendocrine Tumors
File:
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Daniil_Ifigeneia_MSc.pdf
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File access is restricted only to the intranet of UoA.
