Unit:
Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεωνLibrary of the School of Health Sciences
Author:
Stamelos Matthaios
Supervisors info:
Νάστος Κων/νος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Πολίτου Μαριάννα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ματσώτα Παρασκευή, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Περιεγχειρητικές διαταραχές πηκτικότητας στην ενδοκρινική χειρουργική
Translated title:
Perioperative disturbances of coagulation in endocrine surgery
Summary:
Introduction: Primary hyperparathyroidism (PHPT) is an endocrine disorder characterized by increased parathyroid hormone (PTH) secretion and hypercalcemia. Although it has been associated with increased cardiovascular risk, the effects of PHPT on blood coagulation have not been adequately investigated in the current literature.
Aim: The aim of this study is to investigate the relationship between coagulation parameters and PHPT, and the kinetic of recovery of these disorders after surgical treatment of the disease.
Methods: The study follows the methodology of a prospective study in adult patients with diagnosed PHPT and blood concentration of Calcium at least 10,5 mg/dl. The participants (20 patients diagnosed with PHPT) underwent preoperatively routine biochemical tests. PTH, calcium measurements and various coagulation markers including PT, INR, aPTT, D-Dimers, fibrinogen, thromboelastometry (ROTEM) parameters and platelet functionality parameters were evaluated in three different time-
points (Α: before anesthetic induction, B: before reanimation and C : 24 h post-operatively).
Results: In parathyroidectomy patients, significant changes were noted in various coagulation markers and ROTEM parameters between time points, suggesting changes in coagulation after surgical resection.
Conclusions: A drop in Ca values after parathyroidectomy in patients with PHPT could have caused mild coagulability effects, possibly due to the effect of hypocalcaemia on platelet function. This tendency seems to be offset by increased secretion of vWF factor (possibly as a consequence of surgical stress). However, no increased risk of thrombosis was observed. In conclusion, therefore, the fall of Ca does not cause significant disturbances in hemostasis after parathyroidectomy.
Main subject category:
Health Sciences
Keywords:
Primary hyperparathyroidism, Calcium, Parathyroidectomy, Thromboelastometry , Hemostasis
Number of references:
105
File:
File access is restricted until 2024-10-17.
Stamelos_Matthaios_MSc.pdf
2 MB
File access is restricted until 2024-10-17.
