Κατεύθυνση Επεμβατική Καρδιολογία
Library of the School of Health Sciences

2024-04-18

2024

Grassos Dimitrios

Κωνσταντίνος Π. Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Τούσουλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μαρία Δρακοπούλου, Α΄ Καρδιολογική Κλινική, Ιπποκράτειο Νοσοκομείο

Βλάβες του Μυοκαρδίου σε νοσηλευόμενους ασθενείς με λοίμωξη COVID 19

Greek

Myocardial Injuries in hospitalized patients patients with COVID 19 infection

Covid 2019-disease is an infectious disease caused by the novel coronavirus strain SARS-CoV-2 and first appeared in the city of Wuhan, China in December 2019 and has since reached pandemic proportions, adversely affecting the functioning of health system, the global economy and everyday life.The first symptoms include fever, dry cough, fatigue and wheezing, while severe cases can develop into severe pneumonia, acute respiratory distress syndrome, systemic dysfunction of multiple organs, etc. Furthermore, it affects the cardiovascular system, causing severe damage to the myocardium, thus worsening the disease state and negatively affecting the prognosis.The primary cause of cardiovascular complications due to the disease COVID-19 appears to be endothelial dysfunction, and there is also a link with the severe thromboembolic complications at the venous, pulmonary and cerebral levels that have been recorded in many patients, including new patients .Despite the abundance of publications on the effect of the virus on the cardiovascular system, the exact dimensions of involvement and manifestations remain unknown. This happens due to the heterogeneity of the publications but also in the individual case report publications. The purpose of the present study is to highlight, through meta-analysis, the real dimensions of the problem of the effect of the virus on the cardiovascular system.The primary outcome was a composite of disease severity (including critical cases with ICU admission or use of invasive ventilation), adverse disease progression or disease resistance. The secondary outcome was death.The results of the meta-analysis showed that: For the primary outcome of disease severity, we included the presence of smoking which moderately increased the risk for the combined endpoint of disease severity and after restricting the analysis to studies that explicitly report ongoing smoking, the association of smoking with disease severity was not statistically significant.In terms of mortality, smoking was not significantly associated with increased mortality and results were similar in studies that explicitly report smoking habit
Our main findings were (1) that smoking modestly increases the risk of severe disease in hospitalized patients with COVID-19, while mortality data suggest a similar effect size but are currently unclear due to small sample size; and (2) that this increased risk for developing severe disease is more apparent in younger patients without diabetes.

Health Sciences

Covid-19, Myocardial Injury, Hospitalized patients, Treatment.

No

107

Yes

44

107

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https://pergamos.lib.uoa.gr/uoa/dl/object/3396721