Unit:
Κατεύθυνση Βιομηχανική ΦαρμακευτικήLibrary of the School of Science
Author:
Panousaki Polyxeni
Supervisors info:
Δημήτριος Μ. Ρέκκας, Αναπληρωτής Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ,
Παρασκευάς Π. Δάλλας, Επίκουρος Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ,
Αναστασία-Γεωργία Πίππα, Επίκουρη Καθηγήτρια, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Original Title:
Εφαρμογή του σχεδιασμού πειραμάτων στη 3D κατασκευή μικροβελόνων για την εξατομικευμένη διαδερμική χορήγηση φαρμάκων
Translated title:
Application of Design of Experiments in 3D printing of microneedles for personalised transdermal drug delivery
Summary:
Transdermal administration is a particularly easy and attractive for the patient method of drug administration, outperforming conventional per os forms or injections in terms of compliance, sustained release and reduced adverse effects. However, the intrinsic role of the stratum corneum as a barrier significantly limits the number of active substances that can penetrate it.
Microneedles, needle arrays in the μm scale, are a way to increase transdermal permeability by bypassing the stratum corneum. Polymeric dissolvable microneedles in particular are biodegradable, safe and provide the possibility of controlled release of incorporated active ingredients. In this work, a modified micromolding method was applied to fabricate polymeric PVA micro-needles through PLA molds, which utilizes the advantages of 3D FDM printing to simplify the production process. The method was developed in a previous study by the Laboratory of Pharmaceutical Technology, while this study investigated the ability of this method to fabricate microneedle dimensions of different geometries, as well as the effect of geometry on the administered dose. The model drug of choice was ropinirole hydrochloride, a non-ergoline dopamine agonist administered in Parkinson's disease that qualifies for transdermal formulation.
In the above context, Design of Experiments (DoE) was applied, with the selected factors being the length of the base of the microneedles, their height and their number, while the response was the cumulative amount of active that penetrated the skin in ex vivo diffusion cell experiments. Nine different geometric arrays of PVA microneedles were successfully fabricated with high precision, making it possible to personalize the administered dose by altering the geometry of the microneedles within the design space.
Main subject category:
Science
Keywords:
microneedles, transdermal delivery, 3D printing, design of experiments, Ropinirole HCl
File:
File access is restricted until 2027-05-21.
thesis_panousaki.pdf
4 MB
File access is restricted until 2027-05-21.
