Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Sideri Anna-Maria
Dissertation committee:
Ηλίας Γεωργάλας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ- Επιβλέπων
Κωνσταντίνος Δρούτσας, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Παπακωνσταντίνου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Κυμιωνής, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ειρήνη Χατζηράλλη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Πέτρος Πέτρου, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεράσιμος Σιάσος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Προσδιορισμός της αγγείωσης και της αιματικής ροής του χοριοειδούς χιτώνα, των στιβάδων του αμφιβληστροειδούς και της οπτικής θηλής σε ασθενείς με καρδιαγγειακά προβλήματα, μέσω αγγειογραφίας οπτικής τομογραφίας συνοχής
Translated title:
To determine the vascularization and blood flow of the choroid, the retinal and optic layers in patients with cardiovascular problems, by optical coherence tomography angiography
Summary:
Purpose
Οptical coherence tomography angiography (OCTA) offers a detailed view of the retinal capillary circulation. Οur study aimed to investigate the morphological and functional correlation between microvascular retinal changes in optical coherence tomography angiography (OCTA) and the microvascular coronary circulation in patients with ST elevation myocardial infarction (STEMI) coronary heart disease (CHD).
Methods
A total of 330 eyes from 165 participants (88 cases and 77 controls) were enrolled and imaged. Superficial capillary plexus (SCP) and deep capillary plexus (DCP) vascular density was measured in the central (1 mm) and perifoveal (1–3 mm) areas and in the superficial foveal avascular zone (FAZ) and choriocapillaris (3 mm). These parameters were then correlated to the left ventricular ejection fraction (LVEF), and the number of affected coronary arteries.
Results
Decreased vessel densities in the SCP and DCP and choriocapillaris were positively correlated to the LVEF values (P = 0.006, P = 0.026, and P = 0.002, respectively). No statistically significant correlation between the SCP and DCP central area or FAZ area was found. Regarding the number of affected vessels, significant negative correlations were revealed for the SCP and DCP central vessel densities (P < 0.001 and P < 0.001, respectively) and the SCP perifoveal vascular density (P = 0.009).
Conclusions
OCTA vascular indices are significantly correlated with morphological and functional parameters in patients with STEMI CHD. SCP vascular density especially seems to be a promising biomarker for the extent of both macrovascular damage (number of affected coronary arteries) and microvascular damage, as mirrored in the decreased LVEF at admission.
Main subject category:
Health Sciences
Keywords:
Retina plexus, Choroid plexus, Blood flow, Myocardial infraction, Optical coherence tomography angiography
Number of references:
228
