Κατεύθυνση Αναζωογόνηση
Library of the School of Health Sciences

2024-05-09

2024

Katsavarou Dionysia

Μπάκα Σταυρούλα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ξάνθος Θεόδωρος, Καθηγητής, Τμήμα Μαιευτικής, ΠΑΔΑ
Εκμεκτζόγλου Κωνσταντίνος, Επίκουρος Καθηγητής, Τμήμα Ιατρικής, Ευρωπαϊκό Πανεπιστήμιο Κύπρου

Ωσμωτικότητα του πλάσματος ως προγνωστικός δείκτης σε ασθενείς με σηπτικό σοκ

Greek

Serum osmolality in septic shock patients as a simple outcome predictor

Septic shock is a life-threatening condition that requires prompt diagnosis and treatment to improve outcomes in critically ill patients.
Although many factors that are associated with increased mortality in septic shock patients have been identified, the effect of serum osmolarity as a marker of outcome prediction among patients with septic shock has not been studied. The occurrence of sepsis in diabetes mellitus (DM) patients has increased, as the prevalence of DM has increased dramatically worldwide. This research aimed to explore the association between serum osmolarity and mortality in patients with septic shock.
We examined 77 patients with septic shock, 31 of whom had type 2 diabetes (40.26%) from January 2020 to December 2022.
The mean osmolality difference in all patients was 3.13 mmol/L (S.D.= 25.77 mmol/L), while the corresponding changes in subjects with and without T2DM were 1.52 mmol/L (S.D.= 28.17 mmol/L) and 4.22 mmol/L (S.D. =24.28 mmol/L), respectively. In all patients the mean eGFR was 50.15 ml/min (S.D. = 37.02 ml/min), while a higher mean value was observed in patients with diabetes (52.73 ml/min, S.D.= 40.48 ml/min). In all patients and in patients with T2DM, no statistically significant change in osmolality was observed (p value=0.289, p value=0.563, respectively). In contrast, a marginally statistically significant change in osmolality was observed in nondiabetic subjects (p value=0.049), with OSMOmax being on average 4.22 mmol/L greater than OSMO0. Regarding the relationship between osmolality change and mortality, again a statistically significant difference in osmolarity change was observed between those who recovered and those who died among the patients without T2DM (p value=0.038), with those who died showing a greater OSMOmax by 7.94 mmol/L on average from OSMO0, while on the contrary, those patients who recovered showed a lower OSMOmax by 7.63 mmol/L on average from OSMO0. Finally, a statistically significant negative correlation was observed between peak osmolality and the eGFR (Pearson correlation coefficient=-0.30, p value=0.008).

Health Sciences

Serum osmolarity, Septic shock, Diabetes mellitus, eGFR, Outcome predictor

No

0

Yes

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File access is restricted until 2024-12-05.

https://pergamos.lib.uoa.gr/uoa/dl/object/3398054