Κατεύθυνση Κλινική Φαρμακευτική
Library of the School of Science

2024-05-10

2024

Kaligosi Anna

Νικόλαος Δρακούλης, Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ, (Επιβλέπων),
Μιχαήλ Ράλλης, Αναπληρωτής Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ,
Αλέξανδρος Χαλιάσος, Ιατρός – Κλινικός Χημικός, Πρόεδρος Ελληνικής Εταιρείας Κλινικής Χημείας-Κλινικής Βιοχημείας

Θεραπευτική Προσέγγιση της Εμμηνορροϊκής Ημικρανίας: Η Επίδραση Γενετικών Πολυμορφισμών του Υποδοχέα Οιστρογόνων (ESR1)

Greek

Therapeutic Approach of Menstrual Migraine; The Effect of Genetic Polymorphisms of the Estrogen Receptor (ESR1)

Menstrual migraine is a type of migraine which is characterized by a correlation of migraine
crises with the menstrual cycle of a woman and the accompanied hormonal fluctuations. This
neurological disorder is characterized by longer duration and severity of symptoms, as well as
greater resistance to treatment, compared to migraine that is not related to the menstrual
cycle, adversely affecting patients’ quality of life. While its pathophysiology is not fully
understood, the role of estrogen level variations has been marked in several recently published
studies. The potential role of genetic polymorphisms of the Estrogen Receptor 1 gene (ESR1),
which codes Estrogen Receptor a (ERa), in susceptibility for menstrual migraine, has been
under investigation throughout the past years.
In the present study, we investigated the frequency distributions of the genotypes and alleles
for two Single Nucleotide Polymorphisms (SNPs) (rs2234693 or PvuII, rs9340799 or XbaI) of
ESR1, in a sample of Southeastern European Caucasian women. In the following, these data
were compared to data from women of European ancestry, while there were also comparisons
conducted between the Southeastern European Caucasian women sample and 5 population
groups of European women.
For rs2234693, we analyzed data from 378 women of Southeastern European Caucasian
ancestry, aged between 18 to 81 years, while for rs9340799 we used data from 403 women of
Southeastern European Caucasian ancestry, aged between 18 to 81 years. The identification
of their genotypes was accomplished through the use of real-time PCR, following a DNA
extraction process from buccal swab samples. In the following, we performed statistical
analysis and comparisons with data from other population groups of women, acquired from
Ensembl Database.
For rs2234693, after comparisons of genotype and allele frequency distributions of
Southeastern European Caucasian group with other population groups of women, we found
some statistically significant differences in comparison with the group of women of European
ancestry and of Toscani ancestry. For rs9340799, after comparisons of genotype and allele
frequency distributions, some statistically significant differences were found in comparison to
the group of women of European ancestry, as well as the population groups of women of
Finnish, British and Toscani ancestry.
These findings could be useful for the identification of differences with regards to susceptibility
of different population groups of women of European ancestry to menstrual migraine.

Science

Health Sciences

Menstrual Migraine, Genetic Polymorphisms, Estrogen Receptor

Yes

7

Yes

80

78

File access is restricted until 2024-11-21.

https://pergamos.lib.uoa.gr/uoa/dl/object/3398221