Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Dissertation committee:
Γεωργία-Ελένη Θωμοπούλου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ανδρέας Χρ. Λάζαρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αφροδίτη Νόννη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Καβαντζάς, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ειρήνη Θυμαρά, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Κ. Ζωγράφος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευσταθία Γ. Παπαγεωργίου, Καθηγήτρια, Τμήμα Βιοϊατρικών Επιστημών, ΠΑΔΑ
Original Title:
Αναδρομική μελέτη προγνωστικών δεικτών στον καρκίνο του μαστού
Translated title:
Retrospective study of prognostic markers in breast cancer
Summary:
Abstract: Introduction: Breast cancer is a complex disease with variability in clinical manifestation, response to current therapy, and biochemical and histological features among various subgroups. Histologic grading and immunohistochemical evaluation of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 proliferation index play a crucial role in increasing the differential diagnostic value among various types of breast carcinoma.
Purpose: The aim of this study was to determine the histopathological and immunohistochemical characteristics of breast tumors from a University Laboratory of Pathology in Greece and the determination of the predictive and prognostic value of the main immunohistochemical biomarkers in breast cancer.
Method: The study included female patients over 18 years of age, whose histopathological and immunohistochemical reports were stored in the archives of the First Department ofPathology of National and Kapodistrian University of Athens. The study involved 197 female patients with a median age of 70 years and median tumor size of 2.6 cm.
Results: Most tumors were located at the left breast and ductal carcinoma was the most common histologic type (35.5%). Most tumors had histologic grade 2 (106, 53.8%), and were classified as TNM stage IIA (65, 33%). Most grade 1 and 2 tumors exhibited high expression of PR, whereas most grade 3 tumors had no PR expression. Moreover, patients with triple-negative cancer presented with grades 2 and 3 at a lower percentage compared to patients without a triple-negative phenotype (p=0.001).
Conclusions: The study provided valuable insights into the molecular mechanisms involved in the development and progression of breast cancer.Our findings highlight the significance of tumor analysis carried out using immunohistochemistry and histopathological analysis. Moreover, our findings indicate that molecular and immunohistochemical analyses can be helpful in advancing biological understanding and enhance the treatment of breast cancer patients, but also in use of specific prognostic and predictive biomarkers of breast cancer such as ER, PR, HER-2, Ki-67, e-cadherin that they can direct the form of treatment and determine the treatment response of each female patient individually.
Main subject category:
Health Sciences
Keywords:
Breast cancer, Immunohistochemistry, Pathology, Biomarkers, Triple-negative breast cancer, Histopathological subtypes, Molecular subtypes, Histological features, ER, PR, HER-2, Ki-67, e-cadherin, Predictive, Lobular breast carcinoma, Ductal breast carcinoma, Invasive breast carcinoma, In situ breast carcinoma
Number of references:
215
