Speciality Breast Diseases
Library of the School of Health Sciences

2024-05-15

2024

Papadoliopoulou Maria

Νικόλαος Β. Μιχαλόπουλος, Αναπληρωτής Καθηγητής,
Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Αρκαδόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Ζωγράφος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Ανασκόπηση οπτικών τεχνικών ανεύρεσης καρκινικής διήθησης σε μασχαλιαίους λεμφαδένες σε ασθενείς με καρκίνο μαστού

English

Optical imaging method to detect axillary lymph node metastases in breast cancer patients

Breast cancer is the most common malignancy among women and constitutes up to 11,7% of new diagnoses of cancer according to World Health Organization for 2020. TNM grading system (tumor-node-metastasis) is used to evaluate the disease and select the appropriate treatment pathway, depending on characteristics of cancer, regional node metastases and distant metastases.
Lymph node metastases is the most important predictive factor of breast cancer. Recent experimental studies in lymph nodes suggest that spectroscopic/ optical techniques can evaluate and predict lymph node metastases. Bio-optics exploits heterogeneity of tissues in cellular level and disruption of tissue architecture. The interaction of electromagnetic radiation with biological tissue gives rise to several optical effects that are highly relevant to diagnostic applications; they include light reflection, scattering and absorption. Thus, spectroscopic techniques are highlighted as predictive tool of cancerous infiltration and, possibly as an intraoperative tool to recognize lymph node invasion.
The objective of this thesis is to review spectroscopic/ imaging techniques in human lymph node assessment.
In the present article, we review six spectroscopic/imaging techniques that have been used in human lymph nodes, namely: elastic scattering spectroscopy (ESS), optical coherence tomography (OCT), Raman spectroscopy, near- infrared fluorescence imaging (NIRF), diffuse reflectance spectroscopy (DRS) and Fourier transform infrared spectroscopy (FTIR).
Optical imaging has the potential to differentiate between normal and malignant tissues, offering great advantages in terms of speed and diagnostic accuracy. Our results indicate that optical imaging methods can create informative and rapid tools, which could be extremely useful in intraoperative lymph node assessment and surgical decision-making.

Health Sciences

Breast cancer, Axillary lymph nodes, Elastic Scattering Spectroscopy (ESS), Optical Coherence Tomography (OCT), Raman Spectroscopy, Near- Infrared Fluorescence Imaging (NIRF), Diffuse Reflectance Spectroscopy (DRS), Fourier Transform Infrared Spectroscopy (FTIR).

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https://pergamos.lib.uoa.gr/uoa/dl/object/3398609