Unit:
Department of PharmacyLibrary of the School of Science
Author:
Antoniadi Lemonia
Dissertation committee:
κ. Λέανδρος Α. Σκαλτσούνης Καθηγητής, τμήμα Φαρμακευτικής, Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
κ. Σοφία Μητάκου Καθηγήτρια, τμήμα Φαρμακευτικής, Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
κ. Μαρία Χαλαμπαλάκη Αναπληρώτρια Καθηγήτρια, τμήμα Φαρμακευτικής, Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
κ. Ιωάννης Κωστάκης Αναπληρωτής Καθηγητής, τμήμα Φαρμακευτικής, Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
κ. Εμμανουήλ Μικρός Καθηγητής, τμήμα Φαρμακευτικής, Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
κ. Παναγιώτης Μαράκος Καθηγητής, τμήμα Φαρμακευτικής, Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
κ. Φίλιππος Βερβερίδης Καθηγητής, τμήμα Γεωπονίας, Σχολή Γεωπονικών Επιστημών, Ελληνικού Μεσογειακού Πανεπιστημίου (ΕΛΜΕΠΑ)
Original Title:
Σύγχρονες προσεγγίσεις στη φαρμακογνωστική μελέτη παραδοσιακών θεραπευτικών φυτών της οικογένειας Oleaceae.
Translated title:
Phytochemical investigation of traditional medicinal plants of Oleaceae family using modern analytical approaches.
Summary:
The main goal of this doctoral thesis is the phytochemical investigation of significant medicinal species of the Oleaceae family through modern scientific approaches both in terms of methodology and the application of specialized techniques. Olive (Olea europaea) is the most abundant tree in the Mediterranean basin. Its importance is not observed only in nutritional and economic field but also in the promotion of human health, through its biologically active molecules. The development of effective methodologies using "green" techniques for the isolation of bioactive metabolites in large quantities and high purity from olive products will be the initial goal of this study.
The decryption of the chemical composition of olive oil, as well as the correlation of various metabolites with its quality is of great importance. Despite the plethora of scientific studies, there is a class of secondary metabolites in olive oil, the acidified secoiridoid derivatives that remain relatively unknown. Within the framework of this proposal, integrated protocols will be formulated for the semi-synthesis of these derivatives and the correlation of these molecules with quality parameters of olive oil will be evaluated.
On the other hand, the high complexity of the active mixtures of both olive products and herbal extracts makes difficult the attempt to discover new active molecules through traditional methods. Thus, the purpose of the thesis will be the development of an appropriate method, using modern metabolic tools, for the identification of active metabolites of both the phenolic fraction of olive oil and its oxidized form.
Finally, endemic plants of genus Fraxinus have a similar phytochemical content with olive and have been widely used in traditional and modern medicine. These species will be further studied in order to exploit them more effectively.
Main subject category:
Science
Other subject categories:
Health Sciences
Keywords:
Olive oil, Olive Leaves, Green techniques of extraction and isolation, Semisynthesis, Oxidized Compounds, Metabolomics, genus Fraxinus.
Number of references:
254
File:
File access is restricted until 2029-05-20.
PhD_Thesis_Lemonia_Antoniadi.pdf
24 MB
File access is restricted until 2029-05-20.
