Unit:
Κατεύθυνση Εργαστηριακή και Κλινική Νοσηλευτική ΚαρδιολογίαLibrary of the School of Health Sciences
Author:
Vintzilaios Konstantinos
Supervisors info:
Φιλιππάτος Γεράσιμος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παρίσης Ιωάννης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κατσάνος Σπυρίδων, Εξωτερικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μελέτη της καταβολής σε ασθενείς με χρόνια καρδιακή ανεπάρκεια και της σχέσης της με το κλάσμα εξώθησης της αριστερής κοιλίας
Translated title:
Study of fatigue in patients with chronic heart failure and its relationship with left ventricular ejection fraction
Summary:
Overview: Hearth Failure (HF) is an evolving multifactorial syndrome with high morbidity and mortality worldwide. It is accompanied by many physical symptoms, with dyspnea and fatigue being the main ones, with a direct negative impact on patients’ outcome and quality of life.
Aim: To investigate the incidence and severity of fatigue among HF patients and to investigate potential differences in the reported fatigue, according to the ejection fraction (preserved or reduced).Material and Method: The study sample consisted of 50 patients with HF in Primary Health Care, 25 patients with reduced ejection fraction and 25 with preserved. The data collection tool was the Multidimensional Fatigue Inventory-20 (MFI-20) for the self-assessment of fatigue symptoms, which is divided into 5 subscales. The recorded demographical and medical characteristics included sex, age and comorbidities as well as the left ventricular ejection fraction (≥50% preserved and <50% reduced). The statistical analysis was conducted with the SPSS v.25 statistical package and the statistical significance was set at p<0.05.Results: 84.0% of the sample were men and the average age was 66.4±8.7 years. Hypertension was the main co-morbidity (30%) with 54% of the patients having mixed co-morbidities. 50% experienced severe Physical Fatigue while 48% moderate. General Fatigue, Decreased Activity and Decreased Motivation were moderate whereas Mental Fatigue was mild. In patients with reduced ejection fraction fatigue symptoms were more prevalent and of greater severity. A statistically significant correlation was found between reduced ejection fraction and reduced activities capacity (p=0.036) and accomplishing few things (p=0.039). The ejection fraction was correlated with the Reduced Motivation subscale (p=0.022) and more specifically with the decreased pleasurable activities (p=0.007) and the increased feeling of performing nothing (p=0.045). A positive correlation was found between MFI-20 subscales (p=<0.001), expect for Mental Fatigue, which was positively correlated with Reduced Motivation (p=0.006). The ejection fraction emerged as a predictor for Reduced Motivation (p=0.021) since for a decrease by a 1 percentage unit, this subscale’s score increases by 0.24 units. Age was positively correlated with all subscales except Mental Fatigue.Conclusions: Fatigue is a severe symptom of HF and needs early detection and management in order to reduce its frequency and severity
Main subject category:
Health Sciences
Keywords:
Heart failure, Ejection fraction, Fatigue
