Unit:
Speciality Fetal Maternal MedicineLibrary of the School of Health Sciences
Author:
Kouroglou Evgenia
Supervisors info:
Ελευθεριάδης Μακάριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Περβανίδου Παναγιώτα , Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Πανουλής Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Συσχέτιση επιπέδων μητρικής βιταμίνης D με τη νευροανάπτυξη εμβρύου και νεογνού
Translated title:
Association of maternal vitamin D levels with fetal and neonatal neurodevelopment
Summary:
Background: Maternal nutrition during pregnancy plays a crucial role in fetal development, including neurodevelopmental outcomes in offspring. Fetal neurodevelopment seems to be affected by genetic as well as intrauterine and extrauterine factors. There is evidence about the biological role of vitamin D and its receptor in the pathology of abnormal cognitive, communicative functions and mental illnesses. The high percentage of hypovitaminosis D worldwide has become a global health problem that affects all ages, mostly because of its insufficient dietary intake. Maternal 25-hydroxyvitamin D is transferred easily across the placenta, contrarily to breast milk whose secretion is limited, and associated with the process of brain development.
Aim: The aim of this review is to provide an overview of the recent research data in the literature as there is great research interest and new information on the effects of vitamin D deficiency on physical and mental health, in conjunction with the widespread increase in the diagnosis of neurodevelopmental disorders.
Methods: Review of research studies in the literature over the past five years, investigating associations between maternal vitamin D levels during pregnancy and neurodevelopmental outcomes in offspring.
Results: Briefly, the evidence of the studies do not lead to any clear or safe conclusion of association in any category of neurodevelopmental disorders. However, all studies agree that vitamin D sufficiency during pregnancy or childbirth is not related to the appearance of neurodevelopmental manifestations in the offspring.
Conclusions: There is need for specific research protocols in larger study populations, standardized assessment methods and definitions of the diagnosis of disorders, control and neutralization of confounding factors.
Main subject category:
Health Sciences
Keywords:
Vitamin d, Pregnancy, Prenatal screening, Neurodevelopmental disorders, Neurodevelopment
Number of references:
102
