Unit:
Κατεύθυνση Παιδιατρική ΛοιμωξιολογίαLibrary of the School of Health Sciences
Supervisors info:
Βασιλική Παπαευαγγέλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αλεξάνδρα Σολδάτου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σουλτάνα Σιαχανίδου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Αξιολόγηση της ανοσιακής απάντησης στο εμβόλιο της ηπατίτιδας Β σε παιδιά με κοιλιοκάκη
Translated title:
Evaluation of the immmune response to hepatitis B vaccine in chlidren with celiac disease
Summary:
Background: Hepatitis B virus (HBV) vaccine has significantly reduced the prevalence of chronic hepatitis B worldwide. It has been reported that the response rate to HBV vaccination in patients with celiac disease is lower (30%-50%) than in the general population (4%-10%).
Aim: To evaluate the immune response to HBV vaccine in children with celiac disease and compare it to that of healthy controls.
Methods: In this prospective study, 90 children (median age 9,55, IQR:6,9-12,8) with celiac disease under a strict gluten-free diet (GFD) and 93 healthy sex and age-matched controls, all vaccinated against HBV during infancy, were recruited. Anti-HBs IgG serum titers were measured using chemiluminescence method (CLIA, Abbott Alinity i). Children with reduced immune response (anti-HBs titer < 10 mIU/ml) received an additional dose of HBV vaccine and anti-HBs titer was reevaluated four weeks later.
Results: Median age at the administration of the third vaccine dose and at the time of antibody measurement was similar in the two groups. However, the interval between the third dose administration and antibody measurement was significantly longer in children with celiac disease. The percentage of children with positive anti-HBs ( > 10 mIU/ml) was significantly lower in the group of children with celiac disease compared to the controls (p=0.001). Ninety percent of children with celiac disease who were revaccinated developed anti-HBs > 10 mIU/ml following the additional dose.
Conclusions: In this small cohort, the lower anti-HBs IgG titers in children with celiac disease may be attributed to the longer interval between the completion of vaccination and serological testing. Importantly however, HBV immune memory persists in children with celiac disease although the anti-HBs IgG titers decrease over time, as the majority showed a rapid anamnestic response when boosted, indicating that they are provided with long-term protection against the disease and the development of the carrier state.
Main subject category:
Health Sciences
Keywords:
Celiac disease, Children, Hepatitis B vaccine, Anti-HBs IgG titers, Immune response
