Speciality Medical and Surgical Retina Modern Approaches
Library of the School of Health Sciences

2024-07-12

2024

Kazianis Spyridon

Πέτρος Πέτρου, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ραπάνου Ανδρομάχη, Πανεπιστημιακή Υπότροφος, Ιατρική Σχολή, ΕΚΠΑ
Σιάσου Γεωργία, Εντεταλμένη Διδάσκουσα, Ιατρική Σχολή, ΕΚΠΑ

Pachychoroid spectrum. OCT biomarkers in polypoidal choroidal vasculopathy and current aspects in treatment for peripapillary pachychoroid syndrome

English

Pachychoroid spectrum, OCT biomarkers in polypoidal choroidal vasculopathy and current aspects in treatment for peripapillary pachychoroid syndrome

Pachychoroid disease spectrum (PDS) is a relatively recent term that has been used to describe a diffuse or focal choroidal thickening, dilated Haller’s layer vessels (pachyvessels) with attenuation of the Sattler and choriocapillaris layers, as long as choroidal vascular hyperpermeability.
There is an increasing number of phenotypes including central serous chorioretinopathy (CSCR), pachychoroid pigment epitheliopathy, pachychoroidneovasculopathy, polypoidal choroidal vasculopathy/ aneurysmal type 1 neovascularization, peripapillary pachychoroid syndrome, and focal choroidal excavation, as well as two relatively new additions (peripapillary pachychoroid neovasculopathy and peripheral exudative hemorrhagic chorioretinopathy).These conditions are believed to represent different manifestations of a common pathogenic process, as overlapping features have been observed, and progression from one to another can occur. Recognition of these clinical entities is important, so it can be differentiated from other macular disorders that have different pathophysiology and treatment.
Idiopathic polypoidal choroidal vasculopathy(PCV) was first described by Yannuzzi et al.in 1990.In 1995, Spaide and colleagues described the characteristic indocyanine green angiography(ICGA) findings of this disorder which included a branching vascular network with terminal aneurysmal (polypoidal) dilatations. Advances in multimodal imaging, especially of enhanced-depth imaging optical coherence tomography (EDI-OCT) and swept-source optical coherence tomography (SS-OCT) as well as of OCT Angiography (OCT-A) have contributed to the better understanding of PCV.
Peripapillary pachychoroid syndrome (PPS) is a recently reported entity in the PDS spectrum with CSCR-like features that characteristically surround the optic nerve.Treatment options and the efficacy of them for PPS vary.Up to this day there is no conclusion as to which is the appropriate therapy that provides better anatomical or visual results. Although PPS is considered a CSCR variant, the studies evaluating the management of PPS are disproportionate to those of CSCR.

Health Sciences

Pachychoroid spectrum. OCT Biomarkers, PCV/AT1, PPS

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https://pergamos.lib.uoa.gr/uoa/dl/object/3406151