Speciality Periodontology
Βιβλιοθήκη Οδοντιατρικής

2024-07-11

2024

Petsiou Ekaterini-Anna

Δερέκα Ξανθίππη, Αναπληρώτρια Καθηγήτρια, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ
Μπομπέτσης Γεώργιος, Αναπληρωτής Καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ
Κορομάντζος Παναγιώτης, Επίκουρος καθηγητής, Τμήμα Οδοντιατρικής, Σχολή Επιστημών Υγείας, ΕΚΠΑ

Effect of supportive peri-implant care after surgical treatment of peri-implantitis on RANKL and OPG levels in peri-implant crevicular fluid

English

Effect of supportive peri-implant care after surgical treatment of peri-implantitis on RANKL and OPG levels in peri-implant crevicular fluid

Background: Receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) are a system of molecules that regulate bone resorption.
Aim: This study investigated the effect of supportive peri-implant care on the levels of RANKL and OPG in peri-implant crevicular fluid (PICF) and on the clinical parameters, at 6 and 9 months after the surgical treatment of peri-implantitis. Furthermore, comparison between these levels with the levels of RANKL and OPG in PICF of healthy implants was performed.
Material and methods: PICF was obtained from healthy (n=13) and from implants with peri-implantitis 6 and 9 months after surgical treatment (n=13). Visible plaque accumulation, bleeding on probing, and probing depth were assessed at baseline for all groups and at 6 and 9 months after treatment for diseased group. RANKL and OPG concentrations in PICF were measured by enzyme-linked immunosorbent assays.
Results: RANKL concentration was statistically increased at 6 and 9 months compared to 3 months after surgical treatment but lower when compared to the baseline. OPG concentration was significantly higher at 6 and 9 months after surgical treatment of peri- implantitis compared to baseline. There were no differences in RANKL and OPG levels between healthy and treated implants. RANKL/OPG ratio was significantly reduced after treatment compared to baseline. RANKL was positively correlated with PD at 6 and 9 months after surgical treatment of peri-implantitis, and RANKL/OPG ratio was positively correlated with PI decrease at 6 months.
Conclusions: Supportive treatment of peri-implantitis was effective in maintaining stable levels of RANKL and OPG concentrations measured in PICF of surgically treated implants. RANKL-OPG levels might serve as potential molecular biomarkers for peri-implant tissues stability during SPIC. It should be mentioned though that till now, there are no published studies on RANKL and OPG levels during SPIC, thus, more studies are needed for robust conclusions.

Health Sciences

Peri-implantitis, OPG, RANKL, Peri-implant crevicular fluid, Supportive peri-implant care

No

0

Yes

207

86

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/3406201