Unit:
Κατεύθυνση Παιδιατρική ΛοιμωξιολογίαLibrary of the School of Health Sciences
Author:
Giannaki Paschalia
Supervisors info:
Παπαευαγγέλου Βασιλική , Καθηγήτρια, Ιατρική Σχολή , ΕΚΠΑ
Σπυρίδης Νικόλαος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σολδάτου Αλεξάνδρα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίπτωση του έρπητα ζωστήρα στα παιδιά
Translated title:
Herpes zoster incidence in children
Summary:
BACKGROUND: Varicella- Zoster virus (VZV) is a highly contagious human pathogen that belongs in the Herpesviridae family. Acute primary infection leads to varicella, which is usually a childhood disease, while the reactivation of the virus that remains latent in the sensory dorsal root ganglia is called herpes zoster (HZ) and mainly affects adults over 50 years old. Pediatric herpes zoster affects not only immunocompromised children but also healthy ones, both vaccinated and unvaccinated. Herpes zoster is a major health burden worldwide and is expected to increase due to polulation aging and increasing immunosuppressive and steroid use.
PURPOSE: We aim to systematically review literature to examine the incidence of herpes zoster in children, because it is a rare but serious condition.
METHOD: According to PRISMA guidelines, we searched Pubmed and Google Scholar libraries up to February 2024.
RESULTS: We found 30 studies with incidence information that met our eligibility criteria from 12 countries. The incidence rate of herpes zoster in children ranged between 0-354,71/100.000 person-years in our study, more specifically, the incidence rate ranged between 7,5-246/100.000 person-years for North America, between 12-237/100.000 person-years for Europe and between 0-354,71/100.000 person-years in Asia. Incidence was higher in females than males and hospitalization rate found between 0,3-2,7/100.000 person-years. A declining trend for age-specific children’s groups was found in 9 studies, usually after universal varicella immunization program.
CONCLUSION: Future research and surveillance of herpes zoster with comparable methods is needed, especially in children, to reduce morbidity and examine increasing trends.
Main subject category:
Health Sciences
Keywords:
Herpes zoster, Incidence, Children, Adolescents, HZ
File:
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Giannaki_Paschalia_MSc_pdf.pdf
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File access is restricted until 2025-01-12.
