Unit:
Κατεύθυνση Κλινικές Μελέτες: Σχεδιασμός και ΕκτέλεσηLibrary of the School of Health Sciences
Supervisors info:
Λιόντος Μιχαήλ, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ψαλτοπούλου Θεοδώρα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γαβριατοπούλου Μαρία, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
The role of probiotics in the maintenance of remission in adult-onset Crohn’s disease: A Systematic Review
Translated title:
The role of probiotics in the maintenance of remission in adult-onset Crohn’s disease: A Systematic Review
Summary:
BACKGROUND
Inflammatory bowel diseases (IBD), consisting mainly of Crohn’s disease (CD) and Ulcerative Colitis (UC), are chronic illnesses mainly affecting the gastrointestinal tract, but not only. The role of the human gut microbiome in IBD has been established as findings suggest that in CD and UC, certain phyla, though different in each disease, are affected in count and diversity, with dominance of pathogenic bacteria and loss of protective ones. The commonly used pro- and prebiotics are under investigation for their role in the induction and maintenance of remission of IBD, with promising results. Considering the above, the aim of this systematic review is to further investigate the role of probiotics in the maintenance of remission in adult-onset Crohn’s Disease.
MATERIALS & METHODS
The systematic review was conducted according to the recommendations of the Cochrane Handbook for Systematic Reviews and the results were reported following the rules of the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA). Eligible studies were identified in the Cochrane data-base and PubMed; end of search date was the 31st of December 2023.
RESULTS
The search identified a total of 2015 items, of which 11 were included in this systematic review. The find-ings concerning the use of probiotics, either as monotherapy or as adjunctive therapy to traditional treat-ments, in the maintenance of remission of Crohn’s disease were inconclusive, with 4 trials indicating a not statistically significant trend favoring their administration for relapse prevention.
CONCLUSIONS
Although the role of probiotics in Crohn’s disease is doubted, this systematic review highlights the need for further research on the effect of probiotics on the microbiome profiles of IBD patients as well as large-scale, randomized controlled trials with standardized probiotic formulations, aiming at personalized probi-otic therapies with valuable results in Crohn’s disease.
Main subject category:
Health Sciences
Keywords:
Probiotics, Synbiotics, Crohn's Disease, Remission
