Assessment of biomarkers in relation to the type, management and outcome of acute myocardial infarction

Postgraduate Thesis uoadl:3410056 25 Read counter

Unit:
Library of the School of Health Sciences
ΠΜΣ Μονάδες Εντατικής Θεραπείας-Καρδιολογία, Ιατρική και Νοσηλευτική Φροντίδα
Deposit date:
2024-07-19
Year:
2024
Author:
Naki Vasiliki
Supervisors info:
Τούσουλης Δημήτριος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κυρίτση Ελένη Καθηγήτρια Νοσηλευτική Σχολή, Πανεπιστήμιο Δυτικής Αττικής
Τούτουζας Κωνσταντίνος Καθηγητής , Ιατρική Σχολή ,ΕΚΠΑ
Original Title:
Εκτίμηση βιοδεικτών σε σχέση με το είδος , την αντιμετώπιση και την έκβαση του οξέος εμφράγματος του μυοκαρδίου
Languages:
Greek
Translated title:
Assessment of biomarkers in relation to the type, management and outcome of acute myocardial infarction
Summary:
Introduction: Several cardiac biomarkers have emerged as strong predictors of risk among patients presenting with acute coronary syndrome (ACS) and are now regurarly available to clinicians. Elevated troponin I (TnI), high sensitivity C-reactive protein (hs-CRP), and B-type natriuretic peptide (BNP) levels are each associated with higher rates of death and recurrent ischemic events.
Aim: The aim of the present study was to assess biomarker levels in relation to the management, outcome and type of infarction in patients with acute coronary syndrome.
Material and Methods: The study sample consisted of 100 patients who presented to the Emergency Department of a large Public General Hospital of Athens during general on-call days, with symptoms of acute coronary syndrome and were hospitalized in cardiology or cardiac surgery clinics, as well as in infarction units. Data collection was performed by completing a special form to record clinical signs and laboratory/ biochemical/ electrocardiographic and ultrasound tests as recorded in their medical records.
Results: Of the 100 patients in the sample, the majority (81%) were male. The age of 19.0% was 30-50 years old, 45.0% 51-65 years old and 36.0% over 65 years old. From the comparison of biomarker values with the type of acute myocardial infarction, statistically significant differences were found in the admission troponin, where higher values were observed in the anterior ACS (p=0.028) and in the next-day troponin in the lateral-posterior ACS (p<0.001) as well as in the LDH values in the lateral-posterior ACS (p<0.001).
Higher troponin values at admission and next day (p=0.028) and (p<0.001) were observed in STEMI, respectively, as well as in SGOT (p=0.039), LDH (p<0.001) and γ-GT (p=0.018) values. More than five days of hospitalization were experienced by patients with higher next-day troponin (p=0.042), CRP (p<0.001) as well as higher SGOT values (p=0.047).
Conclusion: Biomarker values and especially troponin, SGOT, LDH and CRP are independent factors for type, outcome and hospitalization time.
Main subject category:
Health Sciences
Keywords:
Acute coronary syndrome, STEMI, NSTEMI, Βiomarkers, Οutcome
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
130
Number of pages:
87
File:
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