Library of the School of Health Sciences
ΠΜΣ Μονάδες Εντατικής Θεραπείας-Καρδιολογία, Ιατρική και Νοσηλευτική Φροντίδα

2024-07-19

2024

Naki Vasiliki

Τούσουλης Δημήτριος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κυρίτση Ελένη Καθηγήτρια Νοσηλευτική Σχολή, Πανεπιστήμιο Δυτικής Αττικής
Τούτουζας Κωνσταντίνος Καθηγητής , Ιατρική Σχολή ,ΕΚΠΑ

Εκτίμηση βιοδεικτών σε σχέση με το είδος , την αντιμετώπιση και την έκβαση του οξέος εμφράγματος του μυοκαρδίου

Greek

Assessment of biomarkers in relation to the type, management and outcome of acute myocardial infarction

Introduction: Several cardiac biomarkers have emerged as strong predictors of risk among patients presenting with acute coronary syndrome (ACS) and are now regurarly available to clinicians. Elevated troponin I (TnI), high sensitivity C-reactive protein (hs-CRP), and B-type natriuretic peptide (BNP) levels are each associated with higher rates of death and recurrent ischemic events.
Aim: The aim of the present study was to assess biomarker levels in relation to the management, outcome and type of infarction in patients with acute coronary syndrome.
Material and Methods: The study sample consisted of 100 patients who presented to the Emergency Department of a large Public General Hospital of Athens during general on-call days, with symptoms of acute coronary syndrome and were hospitalized in cardiology or cardiac surgery clinics, as well as in infarction units. Data collection was performed by completing a special form to record clinical signs and laboratory/ biochemical/ electrocardiographic and ultrasound tests as recorded in their medical records.
Results: Of the 100 patients in the sample, the majority (81%) were male. The age of 19.0% was 30-50 years old, 45.0% 51-65 years old and 36.0% over 65 years old. From the comparison of biomarker values with the type of acute myocardial infarction, statistically significant differences were found in the admission troponin, where higher values were observed in the anterior ACS (p=0.028) and in the next-day troponin in the lateral-posterior ACS (p<0.001) as well as in the LDH values in the lateral-posterior ACS (p<0.001).
Higher troponin values at admission and next day (p=0.028) and (p<0.001) were observed in STEMI, respectively, as well as in SGOT (p=0.039), LDH (p<0.001) and γ-GT (p=0.018) values. More than five days of hospitalization were experienced by patients with higher next-day troponin (p=0.042), CRP (p<0.001) as well as higher SGOT values (p=0.047).
Conclusion: Biomarker values and especially troponin, SGOT, LDH and CRP are independent factors for type, outcome and hospitalization time.

Health Sciences

Acute coronary syndrome, STEMI, NSTEMI, Βiomarkers, Οutcome

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0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/3410056