Unit:
Κατεύθυνση Παθολογία της ΚύησηςLibrary of the School of Health Sciences
Supervisors info:
Σοφία Καλανταρίδου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Παπαϊωάννου, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Στρατάκης, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Αγενεσία μεσολοβίου: Προγεννητική διάγνωση, περιγεννητικό αποτέλεσμα, πιθανές συνοδές ανωμαλίες
Translated title:
Corpus callosum agenesis: Prenatal diagnosis, perinatal outcome, possible concomitant abnormalities
Summary:
Corpus callosum agenesis is a nosological entity in which the corpus callosum, by which the two cerebral hemispheres communicate with each other, is partially or completely missing. In fact, there is wide variation in the terminology used to describe corpus callosum lesions. The frequency varies from 0-2.3% depending on the population being investigated. The actual incidence is estimated at 0.3-0.7% in the general population and at 2-3% in the population with affected neurological development. These lesions may be due to genetic causes (may be part of a syndrome), vascular or the effect of some exogenous infectious or toxic agent. However, in less than 50% the cause is identifiable. Τhese lesions often co-exist with a wide range of CNS and extracranial lesions, in 46%, including neuronal migration disorders, interhemispheric cysts, hypertelorism, urinary, gastrointestinal and musculoskeletal lesions. Prenatal diagnosis is based on direct or indirect signs in the 2nd or 3rd trimester ultrasound. In addition to ultrasound, MRI appears to be useful in both confirming the diagnosis and finding coexisting lesions. Prenatal imaging with both US and MRI is important to identify the exact lesion(s) in order to provide proper prenatal information and counseling. If diagnosed prenatally, outcome varies, depending on whether coexisting lesions are present or not. If the finding is isolated the prognosis seems to be similar regardless of whether the agenesis is complete or partial. If there are other intracranial or extracranial lesions the prognosis is much poorer, including intrauterine death, neonatal death, growth retardation, reduced intelligence, seizures.
Main subject category:
Health Sciences
Keywords:
Corpus callosum, Corpus callosum agenesis, Prenatal diagnosis, CNS, Fetal medicine
File:
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andria.pdf
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