Unit:
Κατεύθυνση Γενική και Εξειδικευμένη Παιδιατρική: Κλινική Πράξη και ΈρευναLibrary of the School of Health Sciences
Author:
Koulouriotis Georgios-Christos
Supervisors info:
Νικόλαος Ζάβρας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χρήστος Σαλάκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δέσποινα Μπριάνα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ο ρόλος της υπερχολερυθριναιμίας στην διάγνωση και την εκτίμηση της σοβαρότητας της οξείας σκωληκοειδίτιδας στον παιδιατρικό πληθυσμό της Αθήνας
Translated title:
The role of hyperbilirubinemia in the diagnosis and assessment of the severity of acute appendicitis in the pediatric population of Athens
Summary:
Introduction: Acute appendicitis is one of the most common diseases involving the abdomen in the pediatric population. The incidence worldwide is estimated at 1-2 per 10,000 patients in 0-4 years of age and increases to 25 per 10,000 children in 10-17 years of age. In the last decade several centres around the world have reported a possible association of advanced and severe cases of acute appendicitis (gangrenous, peritonitis) with an increase in blood bilirubin levels in the patient in an adult population. However, so far no study has been conducted to examine this possible association in a paediatric population.
Aim: The aim of this study is to highlight a possible association between bilirubin levels and the severity of acute appendicitis. If demonstrated, we will have an additional tool in our quiver to assess the severity of the condition, particularly in cases where imaging tests cannot help us and provide further information.
Methodology: Patients, who are admitted to our clinic with a possible diagnosis of acute appendicitis, will be examined on consent for blood bilirubin levels over a period of one year from the start of the study. The test results will be compared with intraoperative and pathological findings to determine whether there is indeed a correlation between bilirubin levels and the severity of acute appendicitis.
Results: In a total of 129 patients only 16 patients developed hyperleukemia. Of the 16 patients, 14 patients developed complicated acute appendicitis. Statistical testing revealed a correlation between bilirubin levels and histological type of appendicitis, and hyperbilirubinemia seems to be statistically related to the severity of appendicitis (complicated; non-complicated).
Conclusion: In a cost-effective world, where we are called upon to achieve the best outcome at the lowest cost, bilirubin levels may be an additional diagnostic tool for the reliable diagnosis of appendicitis severity
Main subject category:
Health Sciences
Keywords:
Acute,Appendicitis,Pediatric,Hyperbilirubinemia,Bilirubin
