Unit:
Κατεύθυνση Αναπνευστική Ανεπάρκεια και Μηχανικός ΑερισμόςLibrary of the School of Health Sciences
Author:
Benidis Evangelos
Supervisors info:
Ευμορφία Κονδύλη, Καθηγήτρια, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης, Επιβλέπουσα
Νικολέττα Ροβίνα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μαρία Ντάγανου, Πνευμονολόγος – Εντατικολόγος, Συντονίστρια Διευθύντρια Πολυδύναμης ΜΕΘ, ΓΝΝΘ "Η Σωτηρία"
Original Title:
Effect of different ventilatory settings on mechanical power under isocapnic conditions
Translated title:
Effect of different ventilatory settings on mechanical power under isocapnic conditions
Summary:
As the ventilator-related factors causing VILI essentially reflect the energy transfer from the ventilator to the lung parenchyma, Gattinoni introduced the term “Mechanical Power” (MP), which expresses the aforementioned energy transfer per unit of time. Later, Amato found that of the variables taken into account to calculate MP, only driving pressure and respiratory rate were associated with mortality. This is how the “4xΔP+RR” index was created, which proved to be superior to MP in terms of predicting mortality.
The present work studied in 36 intubated patients the effect of the simultaneous change of tidal volume and respiratory frequency on MP, in order to achieve isocapnic conditions. It was found that increasing the tidal volume from 6, to 8, and finally to 10 ml/Kg of IBW resulted in a statistically significant decrease in MP. In addition, it was shown that the increase of the tidal volume from 6 or 8 ml/Kg to 10 ml/Kg of IBW leads to a statistically significant increase in the “4xΔP+RR” index, while no statistically significant difference was found between 6 and 8 ml /Kg IBW.
Finally, the three components of MP were calculated. It was seen that the reduction of the total MP during the increase of the exhaled volume is due to the clear and statistically significant decrease of the elastic static MP and the resistive MP, while the elastic dynamic MP shows a weak increasing trend (statistically significant between 6 and 8 ml/ Kg of IBW and 6 and 10 ml/Kg of IBW).
Main subject category:
Health Sciences
Keywords:
Mechanical Power, “4xΔP+RR” index, VILI, Isocapnic conditions 
Number of references:
170
File:
File access is restricted until 2025-05-28.
Benidis_Evangelos_MSc.pdf
5 MB
File access is restricted until 2025-05-28.
