Supervisors info:
Ρηγόπουλος Δημήτριος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κατούλης Αλέξανδρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γρηγορίου Σταμάτιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Summary:
Introduction: Psoriasis, atopic dermatitis, rosacea and chronic urticaria are
some of the most common skin diseases encountered in clinical practice. For
complete understanding and optimal therapeutic planning, the study of any
possible association with other concomitant diseases is necessary.
Objectives: The aim of this retrospective study was to record and analyze data
concerning the patient medical history, and the existence of comorbidities with
at least one of psoriasis, atopic dermatitis, rosacea and chronic urticaria. At the
same time, an extensive bibliographic reference is made to the comorbidities
found in the most common skin diseases.
Methods: A total of 86 patients (45 women and 41 men) participated, who
visited the Emergency Department or the Outpatient Department of General
Hospital of Karpenissi and Health Center of Makrakomi or Regional Medical
Center of Agios Georgios Tymfristos as well as the private dermatology clinic,
where I currently work. Data collection included information on gender, age,
smoking history, body weight characteristics, and history of comorbidities, including the presence of arterial hypertension, dyslipidemia, Type 2 Diabetes
Melitus (T2DM), cardiovascular diseases, autoimmune diseases, atopic
comorbidities, gastrointestinal diseases, neoplasms and neuropsychiatric
disorders.
Results: From the multivariate analysis of the study data, a statistically
significant relationship emerges between psoriasis and the existence of
cardiovascular diseases, stroke, arrhythmias and acute Myocardial Infarction,
but also with the individual risk factors for cardiovascular disease, the presence
of arterial hypertension, dyslipidemia and T2DM and high BMI (>27). At the
same time, a correlation between psoriatic disease and neoplasia, existence of
skin carcinoma and depression is noteworthy. Regarding atopic dermatitis, a
statistically significant relationship is detected with food allergy, asthma and
allergic rhinitis, with the factors of the metabolic syndrome, with alopecia
areata and a history of skin infections. The results of the analysis of patients
with rosacea were statistically significant for celiac disease, Parkinson's
disease, history of migraines, and anxiety disorder. Finally, chronic urticaria is
associated with hypothyroidism and vitiligo.
Conclusions: It is necessary for clinicians to record a thorough personal
history, to raise awareness and further inform patients with common skin
diseases about the possibility of comorbidities. With this practice, the severity
of the disease and the general state of health of the patient can be assessed
more accurately. The clinical outcome can be calculated and a more correct
and comprehensive therapeutic approach is carried out. In the present analysis,
the small sample of patients and the difficulty in obtaining the individual
reminder due to incomplete information constituted a disadvantage in the
statistical analysis.
