Unit:
Κατεύθυνση Επεμβατική ΚαρδιολογίαLibrary of the School of Health Sciences
Author:
Stergianos Evangelos
Supervisors info:
Kωνσταντίνος Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ελένη Κυρίτση, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Τούσουλης, Καθηγητής, Ιατρική Σχολή ΕΚΠΑ
Original Title:
Βαθμός ασβεστίου αορτικής βαλβίδας : Ευαισθησία και ειδικότητα με κριτήρια αιμοδυναμικού εργαστηρίου
Translated title:
Aortic valve calcium score : Sensitivity and specificity with hemodynamic criteria
Summary:
Introduction: During the last decade, the use of aortic valve calcium (AVC) score as measured by multidetector computed tomography (MDCT) has gained ground as a reliable, supplemental method of detecting patients with severe aortic stenosis (AS). While its validity has been extensively studied using indirect measures of AS severity by echocardiography, the correlation of AVC and peak-to-peak gradient as measured during left heart catheterization is less well studied.
Purpose: The main aim of the present study is the calculation of the sensitivity and specificity of AVC score using hemodynamic criteria obtained during left heart catheterization. Secondary aims include the investigation of the correlation of AVC score with peak-to-peak gradient in aortic valve, as well as to identify factors that alterate the validity of AVC score in patients with severe AS.
Materials and Methods: We retrospectively reviewed the medical records of 126 patients with tricuspid, degenerative, native valve severe AS planned for transcatheter aortic valve implantation (TAVI) in our hospital. All patients included had MDCT and Doppler echocardiography performed prior the operation while peak to peak gradient was measured during TAVI.
Results: In our study measured sensitivity and specificity was 89% and 27% respectively. While AVC score was positively correlated with peak-to-peak gradient (r=+0,43,p<0,001) in the group with preserved EF, it was not correlated in patients with reduced EF(r=+0,19,p=0,922).
Conclusion: AVC score is characterized by high sensitivity but moderate specificity and, furthermore, it is strongly correlated with peak-to-peak gradient in patients with preserved EF, but not in those with reduced EF.
Main subject category:
Health Sciences
Keywords:
Αortic stenosis, Αortic valve calcium score, Heart computed tomography, Peak-to-peak gradient, Transcatheter aortic valve insertion
