Unit:
Κατεύθυνση Επιδημιολογία-Μεθοδολογία έρευνας στις βιοϊατρικές επιστήμες, την κλινική πράξη και τη δημόσια υγείαLibrary of the School of Health Sciences
Author:
Sotirakis Dimosthenis
Supervisors info:
Παγώνα Λάγιου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Βασιλική Μπενέτου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Δεσύπρης, Βιοστατιστικός, Ιατρική Σχολή ΕΚΠΑ
Original Title:
Συσχέτιση προεγχειρητικού δείκτη αλβουμίνης με τη λοίμωξη χειρουργικού τραύματος σε ασθενείς που υπεβλήθησαν σε χειρουργική επέμβαση λόγω κακοήθειας του πεπτικού συστήματος με ανοιχτή χειρουργική τομή
Translated title:
Preoperative albumin levels and SSI in patients with GI cancer
Summary:
Introduction: Surgical site infection (SSI) is associated with increased morbidity in patients undergoing open surgical procedures. One of the most important factors contributing to the occurrence of this infection is the preoperative nutritional status, with preoperative blood albumin levels serving as a key measurement indicator. The aim of this study was to investigate the potential association of preoperative blood albumin levels with SSI in a sample of patients who underwent surgery due to GI malignancies in Greece.
Materials and Methods: The study involves 202 adult patients who underwent surgery for GI malignancies in the Surgical Department of “Hippocration” General University Hospital of Athens between September 2022 and June 2023. Patients who underwent emergency surgery were excluded from the study. A multivariate logistic regression analysis was performed controlling for a series of factors related to both the disease and albumin levels.
Results: Preoperative albumin levels were found to be statistically significant (p=0.01) in the multivariate logistic regression model, with the likelihood of developing SSI being nearly six times higher in patients with hypoalbuminemia (OR:5.92, 95%CI: 1.47-23.87). Patients with diabetes mellitus had almost four times higher likelihood of developing SSI (OR:3.84, 95%CI: 1.00-14.37) in comparison to those without diabetes. Interestingly, sarcopenia showed a protective role, which was statistically significant in the model.
Discussion-Conclusions: Preoperative hypoalbuminemia is a significant factor for the development of SSI across all models examined, including adjustments for potential confounding factors, in this study sample.
Main subject category:
Health Sciences
Keywords:
SSI, Albumin, Sarcopenia, Open surgery, GI cancer
File:
File access is restricted until 2028-01-15.
Διπλωματική Εργασία-Δημοσθένης Σωτηράκης.pdf
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File access is restricted until 2028-01-15.
