Concordance of genotypic resistance interpretation algorithms in HIV-1 infected patients: An exploratory analysis in Greece

Επιστημονική δημοσίευση - Άρθρο Περιοδικού
uoadl:3003247

Μονάδες

Ερευνητικό υλικό ΕΚΠΑ

Τίτλος

Concordance of genotypic resistance interpretation algorithms in HIV-1 infected patients: An exploratory analysis in Greece

Γλώσσες Τεκμηρίου

Αγγλικά

Περίληψη

Purpose: Genotypic resistance-related mutations in HIV-1 disease are often difficult to interpret. Different algorithms have been developed to provide meaningful application into clinical context. We aimed to compare, for the first time in Greece, the results of genotypic resistance derived from three interpretation algorithms. Methods: The sequences of 120 HIV 1-infected patients were tested for genotypic resistance to 19 antiretroviral (ARV) drugs (n = 2280 sequences). The interpretation results of Rega, ANRS and ViroSeq algorithms were compared. Results: Complete concordance was found for 2/19 ARV drugs, namely lamivudine and emptricitabine. Concordance was high for nucleoside reverse transcriptase inhibitors (NRTIs) and low for protease inhibitors (PIs). In inter-algorithm pairs, agreement was high between Rega and ViroSeq (kappa = 0.701), especially by ARV class, namely NRTIs (k = 0.869) and NNRTIs (k = 0.562). The only exception was noted for rilpivirine, where agreement was higher between ANRS and Rega (k = 0.410) compared to other inter-algorithm pairs (k = 0.018−0.055). By contrast, for PIs all comparisons yielded concordance equivalent to chance (k = 0.000). Conclusions: Our exploratory analysis provided evidence of significant inter-algorithm discordances, especially for PIs and NNRTIs highlighting the importance of matching the results of different algorithms to achieve optimized risk stratification. Ongoing research could assist clinical physicians in interpreting complex genotypic resistance patterns. © 2021 Elsevier B.V.

Έτος δημοσίευσης

2021

Συγγραφείς

Kantzanou, M. Karalexi, M.A. Zivinaki, A. Riza, E. Papachristou, H. Vasilakis, A. Kontogiorgis, C. Linos, A.

Περιοδικό

null

Εκδότης

Elsevier B.V.

Τόμος

137

Τελευταία τροποποίηση

πριν από 3 έτη

Άδεια χρήσης

Creative Commons Αναφορά Δημιουργού-Μη Εμπορική Χρήση 4.0 (CC-BY-NC)

Εξαγωγή Citation

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