Unit:
Κατεύθυνση Βιομηχανική ΦαρμακευτικήLibrary of the School of Science
Author:
Tseliou Aikaterini
Supervisors info:
Δημήτριος Μ. Ρέκκας , Αναπληρωτής Καθηγητής , Φαρμακευτική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών.
Original Title:
Αναπτυξη ενός ευέλικτου συναρμολογούμενου φαρμακευτικού προϊόντος με τη χρήση της τεχνολογίας Dome Matrix® στοχεύοντας στη θεραπεία του H. Pylori.
Translated title:
USE OF DOME MATRIX TECHNOLOGY FOR THE DEVELOPMENT OF A FLOATING DRUG DELIVERY SYSTEM IN THE TREATMENT OF HELICOBACTER PYLORI INFECTION
Summary:
The purpose of this project was the treatment of Helicobacter Pylori by the use of Dome Matrix technology, which allow us to manufacture floating dosage forms that keep the concentration of the antibiotics above the respective minimum inhibitory concentration (MIC) in the stomach for 4–5 hours. In this way, the drug doses and the number of dosage forms administered daily could be reduced, for better patient compliance. The substances used are tetracycline hydrochloride, metronidazole, sucralfate and mastic of Chios. Male Dome Matrix modules of tetracycline and female modules of metronidazole combined in a single dosage form designed to float in the gastric content and to sustain the intra-gastric concentrations of these two antibiotics used for the eradication of Helicobacter pylori. One module of tetracycline and one of metronidazole were assembled by sticking the concave base of one to the concave base of the other, creating an internal void chamber that showed immediate floatation and gastro-retention. Moreover, immediate release modules of sucralfate and mastic of Chios were manufactured as a bilayer tablet, in order to enhance the efficacy of antibiotics against H. pylori. A 00 type hard capsule was used to include two assembled systems of the antibiotics and one of the bilayer tablet as the final configuration. A USP dissolution apparatus II was used for the in vitro drug release of individual modules and assembled system with dissolution medium pH 1.2 and pH 3.5. In the end, were studied the dissolution profiles of the various individual modules and the assembled system, all substantially hydrophilic matrices, in order to analyze the drug release rate and kinetics.
Main subject category:
Science
Other subject categories:
Pharmaceutical technology
Keywords:
Helicobacter Pylori, flexibility, Dome Matrix technology, floatation on the stomach
