Deep brain stimulation for the treatment of epilepsy. Identifying the ideal anatomical target, systematic review of the literature

Postgraduate Thesis uoadl:2914874 9 Read counter

Unit:
Specialty Applied Neuroanatomy
Library of the School of Health Sciences
Deposit date:
2020-05-22
Year:
2020
Author:
Karydakis Ploutarchos
Supervisors info:
Γεώργιος Στράντζαλης, Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ, Επιβλέπων
Μαρία Πιάγκου, Επίκουρη Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
Κωνσταντίνος Φουντάς, Καθηγητής, Τμήμα Ιατρικής, Πανεπιστήμιο Θεσσαλίας
Original Title:
Εν τω βάθει εγκεφαλικός ερεθισμός στην θεραπεία της επιληψίας. Επιλογή του κατάλληλου ανατομικού στόχου, συστηματική ανασκόπηση της βιβλιογραφίας
Languages:
Greek
Translated title:
Deep brain stimulation for the treatment of epilepsy. Identifying the ideal anatomical target, systematic review of the literature
Summary:
Introduction
Deep brain stimulation can effectively decrease the frequency of seizures in patients with drug-resistant epilepsy. However, its exact mechanism of action is still unknown.
The main targets of deep brain stimulation, on the treatment of epilepsy, is the Anterior Thalamic Nucleus (ANT), the Centro-Median Thalamic Nucleus (CMT), the Subthalamic Nucleus (STN), the hippocampus, and the cerebellum.
Aim
Our aim is to describe the anatomy of the targets mentioned above and to identify the identical target, for different types of epileptic seizures, through systematic review of the literature.
Material and Method
A research was conducted in Pubmed and MEDLINE for clinical trials about deep brain stimulation in patients with epilepsy, until the 1st of February 2019. After carefully reviewing the results, we chose 67 trials. The selected articles ware reviewed and presented classified by anatomical target.
Results
19 of the selected articles refer to the Anterior Thalamic Nucleus (ANT), 12 refer to the Centro-Median Thalamic Nucleus (CMT), 15 the Hippocampus, 8 the Subthalamic Nucleus (STN), and 13 the Cerebellum (CB).
Conclusions
Deep brain stimulation (DBS) is a safe procedure that can significantly help patients with drug-resistant epilepsy, by reducing both the frequency and the severity of the seizures. The right choice of anatomical target for each patient, based on our findings, can lead to noteworthy improvement in their quality of life.
Main subject category:
Health Sciences
Keywords:
Deep brain stimulation, Anterior Thalamic Nucleus , Centro-Median Thalamic Nucleus, Hippocampus, Subthalamic Nucleus, Cerebellum
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
225
Number of pages:
96

Karydakis Ploutarchos MSc.pdf
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