Unit:
Κατεύθυνση Κλινικές Μελέτες: Σχεδιασμός και ΕκτέλεσηLibrary of the School of Health Sciences
Supervisors info:
Ψαλτοπούλου Θεοδώρα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γαβριατοπούλου Μαρία, Επίκουρη Καθηγήτρια Ιατρική Σχολή, ΕΚΠΑ
Σεργεντάνης Θεόδωρος, Ακαδημαϊκός Υπότροφος, Ιατρική Σχολή ΕΚΠΑ
Original Title:
Dairy consumption and risk of mood disorders. A systematic review and meta-analysis
Translated title:
Dairy consumption and risk of mood disorders. A systematic review and meta-analysis
Summary:
OBJECTIVE: This systematic review and meta-analysis is part of a hyper-analysis that aims to identify the possible association between dairy product consumption and the risk of mood and cognitive disorders. The present study focuses exclusively dairy intake and mood disorders.
METHODS: The study was conducted according to the PRISMA guidelines. PubMed and Embase were screened for eligible studies from study initiation point until May 31, 2020. Cohort, cross-sectional, case-control studies and clinical trials were deemed eligible. Maximally adjusted effect estimates for relative risk (RR) were extracted. The quantitative synthesis, subanalyses (based on region, study design and degree of adjustment) and sensitivity analyses were performed using a random-effects model.
RESULTS: Eligibility criteria were met by 25 studies (199,118 subjects), which generated 16 study arms in relation to dairy product consumption: 14 for depression, one for postpartum depression, and one for peripartum depression. Risk of depression increased with high-fat milk consumption (pooled RR=1.46, 95% CI: 1.10-1.95), while it was inversely related with higher yogurt intake (pooled RR=0.79, 95% CI: 0.65-0.96) in the sensitivity analysis. Results from the subanalyses were predominantly consistent with the overall analyses.
CONCLUSIONS: Mental health seems to be differently influenced by dairy products, depending on their type, quantity and fat content. Limited available evidence suggests the necessity for additional research given that the global population is aging.
Main subject category:
Health Sciences
Keywords:
Mood disorders, Depression, Dairy, Meta-analysis, Systematic review
