Τίτλος:
Current advantages in the application of proteomics in inflammatory bowel disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Since the formulation of the concept of proteomics, a plethora of proteomic technologies have been developed in order to study proteomes. In inflammatory bowel disease (IBD), several studies use proteomics to try to better understand the disease and discover molecules which can be used as biomarkers. Biomarkers should be able to be used for diagnosis, therapy and prognosis. Although several biomarkers have been discovered, few biomarkers have clinical value. In this review, we analyze and report the current use of proteomic techniques to highlight biomarkers characterizing IBD, and different stages of disease activity. We also report the biomarkers and their potential clinical value. © Springer Science+Business Media, LLC 2012.
Συγγραφείς:
Vaiopoulou, A.
Gazouli, M.
Theodoropoulos, G.
Zografos, G.
Περιοδικό:
Digestive Diseases and Sciences
Λέξεις-κλειδιά:
apolipoprotein A4; apolipoprotein C1; autoantibody; C reactive protein; calgranulin; calgranulin B; cell adhesion molecule; CXCL16 chemokine; cytokine; endothelial leukocyte adhesion molecule 1; exopeptidase; fibrinogen; immunoglobulin; immunoglobulin G; inter alpha trypsin inhibitor; intercellular adhesion molecule 1; interleukin 12p40; interleukin 2; interleukin 2 receptor alpha; interleukin 7; lactoferrin; neutrophil cytoplasmic antibody; orosomucoid; peroxiredoxin 2; plasma protein; protein; proteome; resistin; transforming growth factor beta1; vascular cell adhesion molecule 1, autoimmune disease; colon; Crohn disease; diagnostic value; differential diagnosis; disease activity; disease severity; early diagnosis; enteritis; enzyme linked immunosorbent assay; erythrocyte sedimentation rate; high performance liquid chromatography; human; irritable colon; liquid chromatography; matrix assisted laser desorption ionization time of flight mass spectrometry; peripheral blood mononuclear cell; priority journal; prognosis; protein microarray; protein processing; proteomics; review; sensitivity and specificity; staging; surface enhanced laser desorption ionization time of flight mass spectrometry; two dimensional electrophoresis; two dimensional gel electrophoresis; ulcerative colitis, Biological Markers; Humans; Inflammatory Bowel Diseases; Prognosis; Proteomics
DOI:
10.1007/s10620-012-2291-4
