Τίτλος:
Novel Anti-Inflammatory Agents in COPD: Targeting Lung and Systemic
Inflammation
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Inflammation plays a central role in chronic obstructive pulmonary
disease (COPD). COPD related inflammation is less responsive to inhaled
steroids compared to asthma. There are three major novel
anti-inflammatory approaches to the management of COPD. The first
approach is phosphodiesterase inhibitors, such as roflumilast which
provides additional clinical benefit either as a single agent or as an
additive treatment to long-acting bronchodilators. The second approach
involves novel strategies using drugs licensed for other indications,
such as statins and macrolides; limited prospective studies on these
strategies exist at the moment. A third potential approach involves
novel agents whose mechanism of action is closely related to COPD
mechanisms and pathophysiology. Such novel treatments are of great
interest since they may treat both COPD and co-morbidities. Several
novel agents are currently under development and may be of importance in
the future.
Συγγραφείς:
Loukides, Stelios
Bartziokas, Konstantinos
Vestbo, Jorgen and
Singh, Dave
Περιοδικό:
Current Drug Targets
Εκδότης:
BENTHAM SCIENCE PUBL LTD
Λέξεις-κλειδιά:
Systemic inflammation; COPD; anti-inflammatory agents; statins;
macrolides; phosphodiesterase inhibitors
DOI:
10.2174/1389450111314020008
