Τίτλος:
Histone Deacetylases and their Inhibitors in Colorectal Cancer Therapy: Current Evidence and Future Considerations.
Περίληψη:
Colorectal cancer (CRC) comprises a heterogeneous group of gastrointestinal tract tumors. It is a multifactorial disease, and a plethora of distinct factors are involved in its pathogenesis and pathophysiology. The development of CRC is not limited to genetic changes, but epigenetic and environmental factors are also involved. Among the epigenetic factors, histone deacetylases (HDACs), a group of epigenetic enzymes that regulate gene expression, have been reported to be over-expressed in CRC. HDACs and their inhibitors seem to play an important role in the molecular pathophysiology of CRC. The aim of this review was to define the role of HDAC inhibitors as potential anticancer agents against CRC.
Συγγραφείς:
Garmpis, Nikolaos
Damaskos, Christos
Garmpi, Anna
Nonni, Afroditi
Georgakopoulou, Vasiliki E.
Antoniou, Efstathios
Schizas, Dimitrios
Sarantis, Panagiotis
Patsouras, Alexandros
Syllaios, Athanasios
Vallilas, Christos
Koustas, Evangelos
Kontzoglou, Konstantinos
Trakas, Nikolaos
Dimitroulis, Dimitrios
Περιοδικό:
Current Medicinal Chemistry
Λέξεις-κλειδιά:
*Inhibitors, *Histone, *HDAC, *Colorectal Cancer, *Deacetylase, *Epigenetics, *HDACI, *Targeted Therapy
DOI:
10.2174/0929867328666210915105929
