Περίληψη:
Aims: To summarize the evidence on the association between the intake of legumes and the risk of cardiovascular disease (CVD) overall, coronary heart disease (CHD) and stroke, and to identify optimal intake levels for reduced disease risk through a systematic review and dose–response meta-analysis. Data synthesis: We have systematically searched PubMed, Scopus and Web of Science up to March, 2022 for the retrieval of intervention and observational studies (PROSPERO Reg. number: CRD42021247565). Pooled relative risks (RRs) comparing extreme categories of intake were computed using random-effects models. One-stage dose–response meta-analyses were also performed using random-effects models. 22 831 articles were screened resulting in 26 eligible observational studies (21 prospective cohort and 5 case–control studies). When comparing extreme categories of intake, the consumption of legumes was inversely associated with CVD (n = 25: RR = 0.94; 95%CI:0.89,0.99) and CHD (n = 16: RR = 0.90; 95%CI:0.85,0.96), but not with stroke (n = 9: RR = 1.00; 95%CI:0.93,1.08). We further found evidence for an inverse dose–response association with CHD, increasing in magnitude up to an intake of 400 g/week, after which the benefit seems to level-off. Conclusions: The intake of legumes was associated with a reduced risk of CVD and CHD, but not with stroke, among individuals with the highest consumption levels. An intake level of 400 g/week seemed to provide the optimal cardiovascular benefit. Further research is needed to better understand the role of legumes in stroke subtypes. © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
Συγγραφείς:
Mendes, V.
Niforou, A.
Kasdagli, M.I.
Ververis, E.
Naska, A.
Λέξεις-κλειδιά:
Article; bean; caloric intake; cardiovascular disease; cerebrovascular accident; chickpea; computer assisted tomography; dietary intake; follow up; food frequency questionnaire; food intake; human; insulin sensitivity; ischemic heart disease; legume; lentil; Mediterranean diet; Medline; meta analysis; nuclear magnetic resonance imaging; nutritional assessment; pea; Phaseolus vulgaris; Scopus; sensitivity analysis; soybean; sweet corn; systematic review; tofu; Web of Science; cardiovascular disease; cerebrovascular accident; coronary artery disease; Fabaceae; prospective study; risk factor; vegetable, Cardiovascular Diseases; Coronary Disease; Fabaceae; Humans; Prospective Studies; Risk Factors; Stroke; Vegetables
