Τίτλος:
Hierarchical self-assembly in diblock copolypeptides of poly(γ-benzyl-l-glutamate) with poly poly(l-leucine) and poly(O-benzyl-l-tyrosine)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Block copolypeptides with their inherent nanometer length scale of phase separation, provide means of manipulating the type (α-helices, β-strands) and persistence of peptide secondary structures. Two such examples are employed based on the α-helical poly(γ-benzyl-l- glutamate) (PBLG) polypeptide as one block and poly(l-leucine) (α-helical) or poly(O-benzyl-l-tyrosine) (POBT) (β-strands) as the second block. Although both secondary structures are present in the copolypeptides the effect of nano-scale confinement is to induce folding in the POBT β-sheets and to maintain the defected α-helices of PBLG and PLEU with a limited lateral coherence. © 2010 Elsevier Ltd. All rights reserved.
Συγγραφείς:
M. Mondeshki
H.W. Spiess
T. Aliferis
H. Iatrou
N. Hadjichristidis
G. Floudas
Περιοδικό:
European Polymer Journal
Λέξεις-κλειδιά:
Block copolypeptides; Copolypeptides; Diblocks; Hierarchical self-assembly; L-glutamate; L-leucine; l-Tyrosine; Nano scale; Nanometer length scale; Peptide secondary structures; Secondary structures, Phase separation; Polypeptides; Self assembly, Amino acids
Κύρια θεματική κατηγορία:
Θετικές Επιστήμες
DOI:
10.1016/j.eurpolymj.2010.10.011
