Τίτλος:
Seroepidemiological study of pandemic influenza H1N1 following the 2009-2010 wave in Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Knowledge of seroprevalence rates against 2009 pandemic H1N1 virus will assist vaccination recommendations and the preparation of the health-care system during subsequent years. This study was conducted in Greece during June-August 2010 to estimate the seroprevalence rate against pandemic H1N1 virus. Persons presenting in 29 health-care facilities across the country were studied. Seroprevalence was estimated employing a virus-free ELISA that specifically recognizes 2009 H1N1 virus antibodies in human sera. Sera collected from 2005 to April 2009 were also used to estimate pre-pandemic seroprevalence rates. A total of 954 persons were studied. The overall seroprevalence rate was 28.5% (95% confidence interval =25.6-31.3%). Age-specific rates were 34.2% in persons 0-4 years, 36.3% in persons 5-19 years, 25.0% in persons 20-39 years, 23.4% in persons 40-59 years, and 31.8% in persons ≥60 years. The highest rates were recorded in the Regions of Ionian Islands (67%) and Epirus (42.9%), while the lowest (8.4%) in the Region of Thessaly. Age-specific attack rates of infection during 2009-2010 were 28.8% in persons 0-4 years, 32.5% in persons 5-19 years, 14.3% in persons 20-39 years, 19.1% in persons 40-59 years, and 14.4% in persons ≥60 years. Multivariate analysis revealed that Region of residence and caring for children <5 years were associated with increased risk for seropositivity. Urbanity, personal and family characteristics, working in a health-care facility or in a school, history of pandemic H1N1 vaccination or history of influenza-like illness during 2009-2010 were not associated with increased risk for seropositivity. © 2011 Elsevier Ltd.
Συγγραφείς:
Maltezou, H.C.
Katerelos, P.
Mavrouli, M.
Lourida, A.
Routsias, J.G.
Spanakis, N.
Maragos, A.
Tedoma, A.
Bassiakos, Y.
Koratzanis, G.
Mantagos, S.
Metallidis, S.
Katragkou, A.
Nikolaidis, P.
Roilides, E.
Theodoridou, M.
Tsakris, A.
Λέξεις-κλειδιά:
adolescent; adult; article; child; geographic distribution; Greece; human; infant; infection risk; influenza A (H1N1); Influenza virus A H1N1; major clinical study; pandemic influenza; priority journal; risk assessment; risk factor; seroepidemiology; seroprevalence, Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Antibodies, Viral; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Geography; Greece; Humans; Infant; Infant, Newborn; Influenza A Virus, H1N1 Subtype; Influenza, Human; Male; Middle Aged; Seroepidemiologic Studies; Young Adult
DOI:
10.1016/j.vaccine.2011.06.098
