Τίτλος:
The clinical impact of the eph/ephrin system in cancer: Unwinding the thread
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Erythropoietin‐producing human hepatocellular receptors (EPHs) compose the largest known subfamily of receptor tyrosine kinases (RTKs). They bind and interact with the EPH family receptor interacting proteins (ephrins). EPHs/ephrins are implicated in a variety of physiological processes, as well as in cancer pathogenesis. With neoplastic disease remaining a leading cause of death world‐wide, the development of novel biomarkers aiding in the field of diagnosis, prognosis, and disease monitoring is of utmost importance. A multitude of studies have proven the association between the expression of members of the EPH/ephrin system and various clinicopathological pa-rameters, including disease stage, tumor histologic grade, and patients’ overall survival. Besides their utilization in timely disease detection and assessment of outcome, EPHs/ephrins could also represent possible novel therapeutic targets. The aim of the current review of the literature was to present the existing data regarding the association between EPH/ephrin system expression and the clinical characteristics of malignant tumors. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Pergaris, A.
Danas, E.
Goutas, D.
Sykaras, A.G.
Soranidis, A.
Theocharis, S.
Περιοδικό:
International Journal of Molecular Sciences
Λέξεις-κλειδιά:
ephrin; ephrin receptor A1; tumor marker, human; metabolism; neoplasm; physiology; signal transduction, Biomarkers, Tumor; Ephrins; Humans; Neoplasms; Receptor, EphA1; Signal Transduction
DOI:
10.3390/ijms22168412
