Τίτλος:
Molecular drivers of developmental arrest in the human preimplantation embryo: A systematic review and critical analysis leading to mapping future research
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Developmental arrest of the preimplantation embryo is a multifactorial condition, characterized by lack of cellular division for at least 24 hours, hindering the in vitro fertilization cycle outcome. This systematic review aims to present the molecular drivers of developmental arrest, focusing on embryonic and parental factors. A systematic search in PubMed/Medline, Embase and Cochrane‐Central‐Database was performed in January 2021. A total of 76 studies were included. The identified embryonic factors associated with arrest included gene variations, mitochondrial DNA copy number, methylation patterns, chromosomal abnormalities, metabolic profile and morphological features. Parental factors included, gene variation, protein expression levels and infertility etiology. A valuable conclusion emerging through critical analysis indicated that genetic origins of developmental arrest analyzed from the perspective of parental infertility etiology and the embryo itself, share common ground. This is a unique and long‐overdue contribution to literature that for the first time presents an all‐inclusive methodological report on the molecular drivers leading to preimplantation embryos’ arrested development. The variety and heterogeneity of developmental arrest drivers, along with their inevitable intertwining relationships does not allow for prioritization on the factors playing a more definitive role in arrested development. This systematic review provides the basis for further research in the field. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Sfakianoudis, K.
Maziotis, E.
Karantzali, E.
Kokkini, G.
Grigoriadis, S.
Pantou, A.
Giannelou, P.
Petroutsou, K.
Markomichali, C.
Fakiridou, M.
Koutsilieris, M.
Asimakopoulos, B.
Pantos, K.
Simopoulou, M.
Περιοδικό:
International Journal of Molecular Sciences
Λέξεις-κλειδιά:
mitochondrial DNA; small untranslated RNA, chromosome aberration; embryo; embryo development; female infertility; gene amplification; gene dosage; gene expression; genetic variation; human; preimplantation embryo; protein expression level; Review; systematic review; blastocyst; embryo development; in vitro fertilization; mammalian embryo; pathology, Blastocyst; Embryo, Mammalian; Embryonic Development; Fertilization in Vitro; Humans
DOI:
10.3390/ijms22158353
