Τίτλος:
Tumor dormancy: Implications for invasion and metastasis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Tumor dormancy refers to a critical stage of cancer development when tumor cells are present, but cancer does not progress. It includes both the concept of cellular dormancy, indicating the reversible switch of a cancer cell to a quiescent state, and that of tumor mass dormancy, indicating the presence of neoplastic masses that have reached cell population equilibrium via balanced growth/apoptosis rates. Tumor dormancy provides the conceptual framework, potentially explaining a major challenge in clinical oncology, tumor recurrence, which may occur years after cancer diagnosis. The mechanisms by which tumors are kept dormant, and what triggers their reawakening, are fundamental questions in cancer biology. It seems that a plethora of intracellular pathways and extracellular factors are involved in this process, rewiring the cells to plastically alter their metabolic and proliferative status. This phenomenon is highly dynamic in space and time. Mechanistic insights into both cellular and tumor dormancy have provided the rationale for targeting this otherwise stable period of cancer development, in order to prevent recurrence and maximize therapeutic benefit. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Gomatou, G.
Syrigos, N.
Vathiotis, I.A.
Kotteas, E.A.
Περιοδικό:
International Journal of Molecular Sciences
Λέξεις-κλειδιά:
apoptosis rate; arousal; cancer diagnosis; cancer recurrence; cancer size; cancer staging; cell population; conceptual framework; controlled study; dormancy; human; review; tumor recurrence; animal; apoptosis; autophagy; cancer stem cell; cell proliferation; gene expression regulation; genetics; lymph node metastasis; metabolism; neoplasm; pathology; signal transduction; tumor microenvironment; tumor recurrence, microRNA; mitogen activated protein kinase; tumor protein, Animals; Apoptosis; Autophagy; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; MicroRNAs; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Signal Transduction; Tumor Microenvironment
DOI:
10.3390/ijms22094862
