Τίτλος:
Offensive behavior, striatal glutamate metabolites, and limbic–hypothalamic–pituitary–adrenal responses to stress in chronic anxiety
Περίληψη:
Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Ullmann, E.
Chrousos, G.
Perry, S.W.
Wong, M.-L.
Licinio, J.
Bornstein, S.R.
Tseilikman, O.
Komelkova, M.
Lapshin, M.S.
Vasilyeva, M.
Zavjalov, E.
Shevelev, O.
Khotskin, N.
Koncevaya, G.
Khotskina, A.S.
Moshkin, M.
Cherkasova, O.
Sarapultsev, A.
Ibragimov, R.
Kritsky, I.
Fegert, J.M.
Tseilikman, V.
Yehuda, R.
Λέξεις-κλειδιά:
dehydrocorticosterone; glutamic acid; biological marker; glutamic acid; hormone, aggression; animal behavior; animal experiment; anxiety; Article; behavior change; climbing; controlled study; corticosterone blood level; female; freezing; grooming; hypothalamus hypophysis adrenal system; limbic system; metabolite; nonhuman; predator; rat; stimulus; stress; striate cortex; animal; animal behavior; anxiety; corpus striatum; diagnostic imaging; disease model; etiology; hypophysis adrenal system; hypothalamus; limbic system; male; maze test; mental stress; metabolism; nuclear magnetic resonance imaging; pathophysiology; physiological stress; psychology; spectroscopy, Animals; Anxiety; Behavior, Animal; Biomarkers; Corpus Striatum; Disease Models, Animal; Glutamic Acid; Hormones; Hypothalamus; Limbic System; Magnetic Resonance Imaging; Male; Maze Learning; Pituitary-Adrenal System; Rats; Spectrum Analysis; Stress, Physiological; Stress, Psychological
