Ερευνητικό υλικό ΕΚΠΑ

PEO-b-PCL grafted DPPC liposomes: Physicochemical characterization and stability studies of novel bio-inspired advanced Drug Delivery nano Systems (aDDnSs)

Αγγλικά

Amphiphilic block copolymers and lipids have attracted major scientific interest in recent years due to their intriguing self-assembly behavior, which results in a plethora of nanoassemblies and their potential applications in Pharmaceutical Nanotechnology, as bio-inspired chimeric or hybrid advanced Drug Delivery nano Systems (aDDns). In this work, we report on stability studies of chimeric systems consisted of DPPC (dipalmitoylphosphatidylcholine) and poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) block copolymer in Phosphate Buffer Saline (PBS) and Fetal Bovine Serum (FBS). The incorporation of PEO-b-PCL leads to bio-inspired nanovectors of smaller size, in comparison to DPPC neat liposomes. All the prepared chimeric liposomal formulations were found to retain their original physicochemical characteristics for at least five days. These nanocarriers could be characterized as stealth liposomes due to their biological stability. The composition of the bio-inspired aDDnSs play a key role on their physicochemical and structural properties, as well as on their biological response, which could be a road map for designing aDDnSs based on the bio-inspiration. Copyright © 2014 American Scientific Publishers.

2014

Pippa, N.
Deli, E.
Mentzali, E.
Pispas, S.
Demetzos, C.

Journal of Nanoscience and Nanotechnology

American Scientific Publishers

14

8

5676-5681

Block copolymers; Drug delivery; Liposomes; Nanosystems; Polyethylene oxides; Structural properties, Amphiphilic block copolymers; Colloidal Stability; Dipalmitoyl phosphatidylcholine; Liposomal formulation; Phosphate buffer salines; Physico-chemical characterization; Physicochemical characteristics; Self-assembly behaviors, Stability, liposome; polymer, chemistry; drug delivery system, Drug Delivery Systems; Liposomes; Polymers

https://doi.org/10.1166/jnn.2014.8869

10.1166/jnn.2014.8869

https://pergamos.lib.uoa.gr/uoa/dl/object/2981520