Τίτλος:
Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Novel silybin acylated derivatives with dicarboxylic acids were prepared in various organic solvents using immobilized Candida antarctica lipase B (Novozym 435 ®). The reaction parameters affecting the silybin conversion, such as the nature of the organic solvent and the acyl donor used were investigated. The antiproliferative effects of silybin monoesters, and their ability to modulate the secretion of vascular endothelial growth factor (VEGF) were estimated using K562 human lymphoblastoma cells and compared to the parental compound. The synthesized esters retained the biological function of silybin and in some cases were more effective, indicating that target biotransformation may generate novel compounds with improved antitumor and antiangiogenic activities. © 2011 Elsevier B.V.
Συγγραφείς:
Theodosiou, E.
Loutrari, H.
Stamatis, H.
Roussos, C.
Kolisis, F.N.
Περιοδικό:
New Biotechnology
Λέξεις-κλειδιά:
Acyl donors; Anti-angiogenic activity; Anti-tumor activities; Anti-tumors; Antiproliferative effect; Biocatalytic synthesis; Biological functions; Candida antarctica lipase B; Dicarboxylic acid; Monoesters; Novozym435; Reaction parameters; Silybin; Vascular endothelial growth factor, Endothelial cells; Organic compounds; Organic solvents; Synthesis (chemical), Acylation, dicarboxylic acid derivative; ester; lipase B; silibinin; vasculotropin, antiangiogenic activity; antineoplastic activity; article; cancer cell; Candida antarctica; catalysis; drug structure; drug synthesis; lymphoblastoma; priority journal; solvent extraction, Acetylation; Antineoplastic Agents; Cell Survival; Dicarboxylic Acids; Humans; K562 Cells; Lipase; Silymarin, Candida antarctica
DOI:
10.1016/j.nbt.2011.01.006
