Τίτλος:
Ioniols I and II, tetracyclic diterpenes with antibacterial activity, from Sphaerococcus coronopifolius
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Two naturally occurring diterpenes featuring unprecedented tetracyclic skeletons, ioniols I and II (1 and 2, resp.), along with two previously reported metabolites 3 and 4, were isolated from the organic extract of Sphaerococcus coronopifolius collected from the rocky coasts of Corfu island in the Ionian Sea. The structures of the new natural products, as well as their relative configuration, were elucidated on the basis of extensive spectral analysis, including 2D-NMR experiments. The isolated metabolites were evaluated for their antibacterial activity against a panel of Staphylococcus aureus strains, which included multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains. © 2010 Verlag Helvetica Chimica Acta AG.
Συγγραφείς:
Smyrniotopoulos, V.
Vagias, C.
Rahman, M.M.
Gibbons, S.
Roussis, V.
Περιοδικό:
Chemistry and Biodiversity
Λέξεις-κλειδιά:
diterpene; ioniol I; ioniol II; unclassified drug, antibacterial activity; article; bacterial strain; controlled study; drug isolation; drug structure; methicillin resistant Staphylococcus aureus; nonhuman; nuclear magnetic resonance spectroscopy, Algae, Red; Anti-Bacterial Agents; Diterpenes; Magnetic Resonance Spectroscopy; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Conformation; Staphylococcus aureus, methicillin resistant Staphylococcus aureus; Sphaerococcus coronopifolius; Staphylococcus aureus
DOI:
10.1002/cbdv.200900026
