Τίτλος:
Structure and antibacterial activity of brominated diterpenes from the red alga Sphaerococcus coronopifolius
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Four new tetracyclic brominated diterpenes, 1-4, were isolated from the organic extract of Sphaerococcus coronopifolius, collected from the rocky coasts of Corfu Island. The structures of the new natural products, as well as their relative configurations, were elucidated on the basis of extensive spectral analyses, including 2D-NMR experiments. The isolated metabolites were evaluated for their antibacterial activity against a panel of bacteria including multidrug-resistant (MDR) and methicillinresistant Staphylococcus aureus (MRSA) with MIC values in the range of 16-128 μg/ml. © 2010 Verlag Helvetica Chimica Acta AG.
Συγγραφείς:
Smyrniotopoulos, V.
Vagias, C.
Rahman, M.M.
Gibbons, S.
Roussis, V.
Περιοδικό:
Chemistry and Biodiversity
Λέξεις-κλειδιά:
1 methoxybromotetrasphaerol; 3 bromo 1 deoxybromotetrasphaerol; 3 hydroxy 1 deoxybromotetrasphaerol; 4 hydroxy 1 deoxybromotetrasphaerol; antiinfective agent; norfloxacin; plant extract; Sphaerococcus coronopifolius extract; unclassified drug, antibacterial activity; article; controlled study; drug isolation; medicinal plant; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; multidrug resistance; nonhuman; Sphaerococcus coronopifolius; structure activity relation, Algae, Red; Anti-Bacterial Agents; Diterpenes; Drug Resistance, Multiple; Magnetic Resonance Spectroscopy; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Conformation, Rhodophyta; Sphaerococcus coronopifolius; Staphylococcus aureus
DOI:
10.1002/cbdv.200800309
