Τίτλος:
Increased myeloperoxidase plasma levels in patients with alzheimer's disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Increasing evidence supports the role of cardiovascular risk factors in the development of Alzheimer's disease (AD). Objective: In the present pilot study, we investigated plasma concentrations of myeloperoxidase (MPO) and its possible association with plasma amyloid-β (Aβ) 1-42/1-40 ratio in AD patients and elderly healthy controls. Methods: The study sample included 28 AD patients and 27 elderly individuals with a normal cognitive status as a control group. The Mini-Mental Status Examination was used to determine the global cognition. MPO, Aβ1-40, and Aβ1-42 plasma concentrations were measured by enzyme linked immunoabsorbent assays. Results: AD patients showed significantly higher plasma concentrations of MPO in comparison to healthy elderly controls (AD versus healthy elderly controls (mean ± SD): 132.8 ± 114.8 ng/mL versus 55.0 ± 42.6 ng/mL; p = 0.002). MPO plasma concentrations showed a significant positive correlation in the whole sample with the presence of AD (ρ = 0.428, p < 0.001) and its stage (ρ = 0.331; p = 0.013) as well as with plasma concentrations of Aβ1-42 (ρ = 0.406; p = 0.004) and Aβ1-42/1-40 ratio (ρ = 0.354; p = 0.013). In a binary logistic regression model, plasma MPO concentrations were independently associated with the presence of AD (p = 0.014). Conclusion: AD patients showed significantly increased plasma levels of MPO, which could be an important molecular link between atherosclerosis and AD. Further studies should evaluate whether MPO may also be a useful biomarker and potential new treatment target in AD. © 2014-IOS Press and the authors. All rights reserved.
Συγγραφείς:
Tzikas, S.
Schlak, D.
Sopova, K.
Gatsiou, A.
Stakos, D.
Stamatelopoulos, K.
Stellos, K.
Laske, C.
Περιοδικό:
Journal of Alzheimer's disease : JAD
Λέξεις-κλειδιά:
amyloid beta protein[1-40]; amyloid beta protein[1-42]; biological marker; myeloperoxidase, aged; Alzheimer disease; article; atherosclerosis; blood level; blood sampling; clinical article; controlled study; diabetes mellitus; disease association; dyslipidemia; enzyme immunoassay; female; human; hypertension; male; neurologic disease; priority journal; risk factor; smoking, Alzheimer's disease; amyloid-β; dementia; myeloperoxidase, Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Female; Humans; Immunoenzyme Techniques; Logistic Models; Male; Mental Status Schedule; Neuropsychological Tests; Peptide Fragments; Peroxidase; ROC Curve
