Τίτλος:
Contrasting patterns of deficits in visuospatial memory and executive function in patients with major depression with and without ECT referral
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background The pretreatment neuropsychological profile of drug-resistant patients with major depressive disorder (MDD) referred for electroconvulsive therapy (ECT) may differ from that of their drug-respondent MDD counterparts. Such differences could help in identifying distinct MDD subtypes, thus offering insights into the neuropathology underlying differential treatment responses.Method Depressed patients with ECT referral (ECTs), depressed patients with no ECT referral (NECTs) and non-psychiatric Controls (matched groups, n=15) were assessed with memory and executive function tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).Results ECTs scored significantly lower than NECTs in the Mini-Mental State Examination (MMSE; p=0.01). NECTs performed worse than Controls in the Paired Associates Learning (PAL) task (p<0.03; Control/NECT p<0.01) and the Spatial Recognition Memory (SRM) task (p<0.05; Controls/NECTs p<0.05); ECTs performed between Controls and NECTs, not differing from either. In the Intra/Extradimensional (IED) set-shifting task, ECTs performed worse that Controls and NECTS (IED: p<0.01; Controls/ECTs p<0.01), particularly in the shift phases, which suggests reduced attentional flexibility. In Stockings of Cambridge (SOC), ECTs abandoned the test early more often than Controls and NECTs (H=11, p<0.01) but ECTs who completed SOC performed comparably to the other two groups. Conclusions A double dissociation emerged from the comparison of cognitive profiles of ECT and NECT patients. ECTs showed executive deficits, particularly in attentional flexibility, but mild deficits in tests of visuospatial memory. NECTs presented the opposite pattern. This suggests predominantly frontostriatal involvement in ECT versus temporal involvement in NECT depressives. © Cambridge University Press 2010.
Συγγραφείς:
Tsaltas, E.
Kalogerakou, S.
Papakosta, V.-M.
Kontis, D.
Theochari, E.
Koutroumpi, M.
Anyfandi, E.
Michopoulos, I.
Poulopoulou, C.
Papadimitriou, G.
Oulis, P.
Περιοδικό:
Psychological Medicine
Λέξεις-κλειδιά:
antidepressant agent, article; case control study; cognitive defect; drug resistance; electroconvulsive therapy; executive function; female; Greece; human; major depression; memory disorder; middle aged; neuropsychological test; statistical analysis; treatment failure, Antidepressive Agents; Case-Control Studies; Cognition Disorders; Depressive Disorder, Major; Drug Resistance; Electroconvulsive Therapy; Executive Function; Female; Greece; Humans; Matched-Pair Analysis; Memory Disorders; Middle Aged; Neuropsychological Tests; Treatment Failure
DOI:
10.1017/S0033291710001443
